237806

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 999267..999892 Replicon chromosome
Accession NZ_CP093212
Organism Staphylococcus epidermidis strain TSM-51

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag MNU32_RS04725 Protein ID WP_002504557.1
Coordinates 999497..999892 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag MNU32_RS04720 Protein ID WP_002504558.1
Coordinates 999267..999497 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU32_RS04655 (MNU32_04655) 994336..994818 + 483 WP_002504570.1 hypothetical protein -
MNU32_RS04660 (MNU32_04660) 994834..995013 + 180 WP_002504569.1 hypothetical protein -
MNU32_RS04665 (MNU32_04665) 994998..995183 + 186 WP_001187008.1 hypothetical protein -
MNU32_RS04670 (MNU32_04670) 995199..995483 + 285 WP_002504568.1 hypothetical protein -
MNU32_RS04675 (MNU32_04675) 995480..995635 + 156 WP_002504567.1 transcriptional activator RinB -
MNU32_RS04680 (MNU32_04680) 995661..995933 + 273 WP_002504566.1 hypothetical protein -
MNU32_RS04685 (MNU32_04685) 995949..996491 + 543 WP_002504565.1 hypothetical protein -
MNU32_RS04690 (MNU32_04690) 996484..996660 + 177 WP_002504564.1 hypothetical protein -
MNU32_RS04695 (MNU32_04695) 996680..996901 + 222 WP_002504563.1 hypothetical protein -
MNU32_RS04700 (MNU32_04700) 996901..997626 + 726 WP_010959229.1 metallophosphoesterase -
MNU32_RS04705 (MNU32_04705) 997619..997936 + 318 WP_002504561.1 hypothetical protein -
MNU32_RS04710 (MNU32_04710) 997936..998586 + 651 WP_002504560.1 hypothetical protein -
MNU32_RS04715 (MNU32_04715) 998586..999104 + 519 WP_002504559.1 metallophosphoesterase -
MNU32_RS04720 (MNU32_04720) 999267..999497 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
MNU32_RS04725 (MNU32_04725) 999497..999892 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MNU32_RS04730 (MNU32_04730) 1000370..1000639 + 270 WP_000755772.1 hypothetical protein -
MNU32_RS04735 (MNU32_04735) 1000696..1001190 + 495 WP_010959224.1 hypothetical protein -
MNU32_RS04740 (MNU32_04740) 1001194..1001994 + 801 WP_000686449.1 metallophosphoesterase -
MNU32_RS04745 (MNU32_04745) 1002103..1002825 + 723 WP_002504538.1 hypothetical protein -
MNU32_RS04750 (MNU32_04750) 1002931..1003572 + 642 WP_002504537.1 hypothetical protein -
MNU32_RS04755 (MNU32_04755) 1003820..1004224 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 898707..1032571 133864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T237806 WP_002504557.1 NZ_CP093212:999497-999892 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T237806 NZ_LR882963:4547162-4547560 [Planktothrix agardhii]
GTGAAATTATTGTTGGATACCCAATGCTGGTTATGGTGGTTTGCCCAACCTGAGCGATTAAATCAGGAAGTGATCGCACA
GATTGCCGATGAAAGTAATGAATTATGGTTTTCTGTTGCTAGTGTTTGGGAAATTGGGATTAAAGTTGCGATCAGAAAAT
TACCATTACCAGAGCCAATAGATACCTACATTTCTAGTCGTATGGTGCAGTTAGATATGCGATATTTGGAAATCACAGCA
CCTCATGCACTGCGATCATCTGCGTTACCATTACATCATCGAGATCCCTTTGATCGTATGTTGATTGCTCAGGCTCAGAT
TGAGGATATGACGCTGGTAAGTGCTGATTCAATGTTCAAGCAATACAGCGATATTTCTGTTCTTTGGGCTGCTAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT237806 WP_002504558.1 NZ_CP093212:999267-999497 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT237806 NZ_LR882963:4546917-4547165 [Planktothrix agardhii]
ATTCAGATTGAAAACTTACCCAACGACTTCAAAAAAAATCTCTCTGAGTTATTGTCCCGTGTAGAACTTGGAGAAGAAAT
TATTATTTCCAATCAAGGGGTGGCGATCGCTAAGTTAATTCCGTTTCGTCCTTCATCCAATCGACGGGCGAGTTTAGGGC
AAGATCAAGGTAAATTTATCATACCAGATGACTTTAATGAACCGTTACCCCAAGAAATTTTGGCAGCATTTGAAGGAAAT
GAACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References