Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 826946..827571 Replicon chromosome
Accession NZ_CP073852
Organism Staphylococcus epidermidis strain B1266915

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV26_RS04215 Protein ID WP_002504557.1
Coordinates 827176..827571 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV26_RS04210 Protein ID WP_002504558.1
Coordinates 826946..827176 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV26_RS04145 (KFV26_04145) 822015..822497 + 483 WP_002504570.1 hypothetical protein -
KFV26_RS04150 (KFV26_04150) 822513..822692 + 180 WP_002504569.1 hypothetical protein -
KFV26_RS04155 (KFV26_04155) 822677..822862 + 186 WP_001187008.1 hypothetical protein -
KFV26_RS04160 (KFV26_04160) 822878..823162 + 285 WP_002504568.1 hypothetical protein -
KFV26_RS04165 (KFV26_04165) 823159..823314 + 156 WP_002504567.1 transcriptional activator RinB -
KFV26_RS04170 (KFV26_04170) 823340..823612 + 273 WP_002504566.1 hypothetical protein -
KFV26_RS04175 (KFV26_04175) 823628..824170 + 543 WP_002504565.1 hypothetical protein -
KFV26_RS04180 (KFV26_04180) 824163..824339 + 177 WP_002504564.1 hypothetical protein -
KFV26_RS04185 (KFV26_04185) 824359..824580 + 222 WP_002504563.1 hypothetical protein -
KFV26_RS04190 (KFV26_04190) 824580..825305 + 726 WP_010959229.1 metallophosphoesterase -
KFV26_RS04195 (KFV26_04195) 825298..825615 + 318 WP_002504561.1 hypothetical protein -
KFV26_RS04200 (KFV26_04200) 825615..826265 + 651 WP_002504560.1 hypothetical protein -
KFV26_RS04205 (KFV26_04205) 826265..826783 + 519 WP_002504559.1 metallophosphoesterase -
KFV26_RS04210 (KFV26_04210) 826946..827176 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV26_RS04215 (KFV26_04215) 827176..827571 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV26_RS04220 (KFV26_04220) 827874..828065 + 192 WP_002504556.1 hypothetical protein -
KFV26_RS04225 (KFV26_04225) 828049..828318 + 270 WP_000755772.1 hypothetical protein -
KFV26_RS04230 (KFV26_04230) 828375..828869 + 495 WP_010959224.1 hypothetical protein -
KFV26_RS04235 (KFV26_04235) 828873..829673 + 801 WP_000686449.1 metallophosphoesterase -
KFV26_RS04240 (KFV26_04240) 829782..830504 + 723 WP_002504538.1 hypothetical protein -
KFV26_RS04245 (KFV26_04245) 830610..831251 + 642 WP_002504537.1 hypothetical protein -
KFV26_RS12925 831282..831416 - 135 WP_002504536.1 hypothetical protein -
KFV26_RS04250 (KFV26_04250) 831499..831903 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 718947..859143 140196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200399 WP_002504557.1 NZ_CP073852:827176-827571 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200399 NZ_CP097840:4053913-4054143 [Shigella flexneri]
ATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGACGGGCTTTTCGAACTCAGAATTAAAGG
CAACGATGGGATCGCGCGTGTTTTTTACTGCACTCTGACAGGGAAACGCATCATCATGCTGCATAGTTTTGTAAAGAAAG
CGCAGAAAACACCGCCAGCCGAACGCAAGAAAGCTGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200399 WP_002504558.1 NZ_CP073852:826946-827176 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200399 NZ_CP097840:4054133-4054441 [Shigella flexneri]
ATGACTGGTAAACGCACTCTCCCCACCATGACACACGACGAAATGGCAGCCAAATGGATGGAAGACCCGGCTTTTAAAGC
AGAATACGACGCTATCGCTGACGAATTCGCACTGCTTGATGAAATGCTGGCAGCACGCAAAGAAGCTGGCTTAACTCAGG
CTGAAGTTGCCGAGCGAATGGGAACAAAAGCGACCGCGATCACCAGAATGGAAAGTAATCTCGCATCAGGTATCAGCGGC
CCATCATTTGCCACACTAAAAAAATTCGCCCGCGCTACTGGAAAAAAACTCCAGATCCGCTTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References