200407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1890575..1891200 Replicon chromosome
Accession NZ_CP073857
Organism Staphylococcus epidermidis strain B1272014

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV47_RS09010 Protein ID WP_002504557.1
Coordinates 1890575..1890970 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV47_RS09015 Protein ID WP_002504558.1
Coordinates 1890970..1891200 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV47_RS08975 (KFV47_08985) 1886243..1886647 + 405 WP_002504535.1 YolD-like family protein -
KFV47_RS14020 1886730..1886864 + 135 WP_002504536.1 hypothetical protein -
KFV47_RS08980 (KFV47_08990) 1886895..1887536 - 642 WP_002504537.1 hypothetical protein -
KFV47_RS08985 (KFV47_08995) 1887642..1888364 - 723 WP_002504538.1 hypothetical protein -
KFV47_RS08990 (KFV47_09000) 1888473..1889273 - 801 WP_000686449.1 metallophosphoesterase -
KFV47_RS08995 (KFV47_09005) 1889277..1889771 - 495 WP_010959224.1 hypothetical protein -
KFV47_RS09000 (KFV47_09010) 1889828..1890097 - 270 WP_000755772.1 hypothetical protein -
KFV47_RS09005 (KFV47_09015) 1890081..1890272 - 192 WP_002504556.1 hypothetical protein -
KFV47_RS09010 (KFV47_09020) 1890575..1890970 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV47_RS09015 (KFV47_09025) 1890970..1891200 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV47_RS09020 (KFV47_09030) 1891363..1891881 - 519 WP_002504559.1 metallophosphoesterase -
KFV47_RS09025 (KFV47_09035) 1891881..1892531 - 651 WP_002504560.1 hypothetical protein -
KFV47_RS09030 (KFV47_09040) 1892531..1892848 - 318 WP_002504561.1 hypothetical protein -
KFV47_RS09035 (KFV47_09045) 1892841..1893566 - 726 WP_010959229.1 metallophosphoesterase -
KFV47_RS09040 (KFV47_09050) 1893566..1893787 - 222 WP_002504563.1 hypothetical protein -
KFV47_RS09045 (KFV47_09055) 1893807..1893983 - 177 WP_002504564.1 hypothetical protein -
KFV47_RS09050 (KFV47_09060) 1893976..1894518 - 543 WP_002504565.1 hypothetical protein -
KFV47_RS09055 (KFV47_09065) 1894534..1894806 - 273 WP_002504566.1 hypothetical protein -
KFV47_RS09060 (KFV47_09070) 1894832..1894987 - 156 WP_002504567.1 transcriptional activator RinB -
KFV47_RS09065 (KFV47_09075) 1894984..1895268 - 285 WP_002504568.1 hypothetical protein -
KFV47_RS09070 (KFV47_09080) 1895284..1895469 - 186 WP_001187008.1 hypothetical protein -
KFV47_RS09075 (KFV47_09085) 1895454..1895633 - 180 WP_002504569.1 hypothetical protein -
KFV47_RS09080 (KFV47_09090) 1895649..1896131 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1857897..1999199 141302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200407 WP_002504557.1 NZ_CP073857:c1890970-1890575 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200407 NZ_CP097841:c197894-197412 [Shigella flexneri]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200407 WP_002504558.1 NZ_CP073857:c1891200-1890970 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200407 NZ_CP097841:c198187-197885 [Shigella flexneri]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References