Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-doc |
Location | 1893073..1893698 | Replicon | chromosome |
Accession | NZ_CP073872 | ||
Organism | Staphylococcus epidermidis strain B1282731 |
Toxin (Protein)
Gene name | doc | Uniprot ID | Q5HMS9 |
Locus tag | KFV34_RS09105 | Protein ID | WP_002504557.1 |
Coordinates | 1893073..1893468 (-) | Length | 132 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | A0A4Y7VKS9 |
Locus tag | KFV34_RS09110 | Protein ID | WP_002504558.1 |
Coordinates | 1893468..1893698 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFV34_RS09070 (KFV34_09080) | 1888741..1889145 | + | 405 | WP_002504535.1 | YolD-like family protein | - |
KFV34_RS13450 | 1889228..1889362 | + | 135 | WP_002504536.1 | hypothetical protein | - |
KFV34_RS09075 (KFV34_09085) | 1889393..1890034 | - | 642 | WP_002504537.1 | hypothetical protein | - |
KFV34_RS09080 (KFV34_09090) | 1890140..1890862 | - | 723 | WP_002504538.1 | hypothetical protein | - |
KFV34_RS09085 (KFV34_09095) | 1890971..1891771 | - | 801 | WP_000686449.1 | metallophosphoesterase | - |
KFV34_RS09090 (KFV34_09100) | 1891775..1892269 | - | 495 | WP_010959224.1 | hypothetical protein | - |
KFV34_RS09095 (KFV34_09105) | 1892326..1892595 | - | 270 | WP_000755772.1 | hypothetical protein | - |
KFV34_RS09100 (KFV34_09110) | 1892579..1892710 | - | 132 | WP_257243913.1 | hypothetical protein | - |
KFV34_RS09105 (KFV34_09115) | 1893073..1893468 | - | 396 | WP_002504557.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
KFV34_RS09110 (KFV34_09120) | 1893468..1893698 | - | 231 | WP_002504558.1 | addiction module antitoxin | Antitoxin |
KFV34_RS09115 (KFV34_09125) | 1893861..1894379 | - | 519 | WP_002504559.1 | metallophosphoesterase | - |
KFV34_RS09120 (KFV34_09130) | 1894379..1895029 | - | 651 | WP_002504560.1 | hypothetical protein | - |
KFV34_RS09125 (KFV34_09135) | 1895029..1895346 | - | 318 | WP_002504561.1 | hypothetical protein | - |
KFV34_RS09130 (KFV34_09140) | 1895339..1896064 | - | 726 | WP_010959229.1 | metallophosphoesterase | - |
KFV34_RS09135 (KFV34_09145) | 1896064..1896285 | - | 222 | WP_002504563.1 | hypothetical protein | - |
KFV34_RS09140 (KFV34_09150) | 1896305..1896481 | - | 177 | WP_002504564.1 | hypothetical protein | - |
KFV34_RS09145 (KFV34_09155) | 1896474..1897016 | - | 543 | WP_002504565.1 | hypothetical protein | - |
KFV34_RS09150 (KFV34_09160) | 1897032..1897304 | - | 273 | WP_002504566.1 | hypothetical protein | - |
KFV34_RS09155 (KFV34_09165) | 1897330..1897485 | - | 156 | WP_002504567.1 | transcriptional activator RinB | - |
KFV34_RS09160 (KFV34_09170) | 1897482..1897766 | - | 285 | WP_002504568.1 | hypothetical protein | - |
KFV34_RS09165 (KFV34_09175) | 1897782..1897967 | - | 186 | WP_001187008.1 | hypothetical protein | - |
KFV34_RS09170 (KFV34_09180) | 1897952..1898131 | - | 180 | WP_002504569.1 | hypothetical protein | - |
KFV34_RS09175 (KFV34_09185) | 1898147..1898629 | - | 483 | WP_002504570.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | aac(6')-aph(2'') | - | 1861501..1994445 | 132944 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14992.31 Da Isoelectric Point: 9.4885
>T200437 WP_002504557.1 NZ_CP073872:c1893468-1893073 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK
Download Length: 396 bp
>T200437 NZ_CP097881:c606394-605930 [Escherichia coli str. K-12 substr. MG1655]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8648.89 Da Isoelectric Point: 5.1231
>AT200437 WP_002504558.1 NZ_CP073872:c1893698-1893468 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL
Download Length: 231 bp
>AT200437 NZ_CP097881:c606729-606394 [Escherichia coli str. K-12 substr. MG1655]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4Y7VKP2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4Y7VKS9 |