Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1893073..1893698 Replicon chromosome
Accession NZ_CP073872
Organism Staphylococcus epidermidis strain B1282731

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV34_RS09105 Protein ID WP_002504557.1
Coordinates 1893073..1893468 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV34_RS09110 Protein ID WP_002504558.1
Coordinates 1893468..1893698 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV34_RS09070 (KFV34_09080) 1888741..1889145 + 405 WP_002504535.1 YolD-like family protein -
KFV34_RS13450 1889228..1889362 + 135 WP_002504536.1 hypothetical protein -
KFV34_RS09075 (KFV34_09085) 1889393..1890034 - 642 WP_002504537.1 hypothetical protein -
KFV34_RS09080 (KFV34_09090) 1890140..1890862 - 723 WP_002504538.1 hypothetical protein -
KFV34_RS09085 (KFV34_09095) 1890971..1891771 - 801 WP_000686449.1 metallophosphoesterase -
KFV34_RS09090 (KFV34_09100) 1891775..1892269 - 495 WP_010959224.1 hypothetical protein -
KFV34_RS09095 (KFV34_09105) 1892326..1892595 - 270 WP_000755772.1 hypothetical protein -
KFV34_RS09100 (KFV34_09110) 1892579..1892710 - 132 WP_257243913.1 hypothetical protein -
KFV34_RS09105 (KFV34_09115) 1893073..1893468 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV34_RS09110 (KFV34_09120) 1893468..1893698 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV34_RS09115 (KFV34_09125) 1893861..1894379 - 519 WP_002504559.1 metallophosphoesterase -
KFV34_RS09120 (KFV34_09130) 1894379..1895029 - 651 WP_002504560.1 hypothetical protein -
KFV34_RS09125 (KFV34_09135) 1895029..1895346 - 318 WP_002504561.1 hypothetical protein -
KFV34_RS09130 (KFV34_09140) 1895339..1896064 - 726 WP_010959229.1 metallophosphoesterase -
KFV34_RS09135 (KFV34_09145) 1896064..1896285 - 222 WP_002504563.1 hypothetical protein -
KFV34_RS09140 (KFV34_09150) 1896305..1896481 - 177 WP_002504564.1 hypothetical protein -
KFV34_RS09145 (KFV34_09155) 1896474..1897016 - 543 WP_002504565.1 hypothetical protein -
KFV34_RS09150 (KFV34_09160) 1897032..1897304 - 273 WP_002504566.1 hypothetical protein -
KFV34_RS09155 (KFV34_09165) 1897330..1897485 - 156 WP_002504567.1 transcriptional activator RinB -
KFV34_RS09160 (KFV34_09170) 1897482..1897766 - 285 WP_002504568.1 hypothetical protein -
KFV34_RS09165 (KFV34_09175) 1897782..1897967 - 186 WP_001187008.1 hypothetical protein -
KFV34_RS09170 (KFV34_09180) 1897952..1898131 - 180 WP_002504569.1 hypothetical protein -
KFV34_RS09175 (KFV34_09185) 1898147..1898629 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1861501..1994445 132944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200437 WP_002504557.1 NZ_CP073872:c1893468-1893073 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200437 NZ_CP097881:c606394-605930 [Escherichia coli str. K-12 substr. MG1655]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200437 WP_002504558.1 NZ_CP073872:c1893698-1893468 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200437 NZ_CP097881:c606729-606394 [Escherichia coli str. K-12 substr. MG1655]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References