200469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822259..822884 Replicon chromosome
Accession NZ_CP073890
Organism Staphylococcus epidermidis strain V1933793

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV31_RS04250 Protein ID WP_002504557.1
Coordinates 822489..822884 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV31_RS04245 Protein ID WP_002504558.1
Coordinates 822259..822489 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV31_RS04180 (KFV31_04180) 817328..817810 + 483 WP_002504570.1 hypothetical protein -
KFV31_RS04185 (KFV31_04185) 817826..818005 + 180 WP_002504569.1 hypothetical protein -
KFV31_RS04190 (KFV31_04190) 817990..818175 + 186 WP_001187008.1 hypothetical protein -
KFV31_RS04195 (KFV31_04195) 818191..818475 + 285 WP_002504568.1 hypothetical protein -
KFV31_RS04200 (KFV31_04200) 818472..818627 + 156 WP_002504567.1 transcriptional activator RinB -
KFV31_RS04205 (KFV31_04205) 818653..818925 + 273 WP_002504566.1 hypothetical protein -
KFV31_RS04210 (KFV31_04210) 818941..819483 + 543 WP_002504565.1 hypothetical protein -
KFV31_RS04215 (KFV31_04215) 819476..819652 + 177 WP_002504564.1 hypothetical protein -
KFV31_RS04220 (KFV31_04220) 819672..819893 + 222 WP_002504563.1 hypothetical protein -
KFV31_RS04225 (KFV31_04225) 819893..820618 + 726 WP_010959229.1 metallophosphoesterase -
KFV31_RS04230 (KFV31_04230) 820611..820928 + 318 WP_002504561.1 hypothetical protein -
KFV31_RS04235 (KFV31_04235) 820928..821578 + 651 WP_002504560.1 hypothetical protein -
KFV31_RS04240 (KFV31_04240) 821578..822096 + 519 WP_002504559.1 metallophosphoesterase -
KFV31_RS04245 (KFV31_04245) 822259..822489 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV31_RS04250 (KFV31_04250) 822489..822884 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV31_RS04255 (KFV31_04255) 823187..823378 + 192 WP_002504556.1 hypothetical protein -
KFV31_RS04260 (KFV31_04260) 823362..823631 + 270 WP_000755772.1 hypothetical protein -
KFV31_RS04265 (KFV31_04265) 823688..824182 + 495 WP_010959224.1 hypothetical protein -
KFV31_RS04270 (KFV31_04270) 824186..824986 + 801 WP_000686449.1 metallophosphoesterase -
KFV31_RS04275 (KFV31_04275) 825095..825817 + 723 WP_002504538.1 hypothetical protein -
KFV31_RS04280 (KFV31_04280) 825923..826564 + 642 WP_002504537.1 hypothetical protein -
KFV31_RS13560 826595..826729 - 135 WP_002504536.1 hypothetical protein -
KFV31_RS04285 (KFV31_04285) 826812..827216 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721512..855562 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200469 WP_002504557.1 NZ_CP073890:822489-822884 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200469 NZ_CP097882:c1119012-1117939 [Escherichia coli str. K-12 substr. MG1655]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200469 WP_002504558.1 NZ_CP073890:822259-822489 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200469 NZ_CP097882:c1117946-1117575 [Escherichia coli str. K-12 substr. MG1655]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References