200449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822228..822853 Replicon chromosome
Accession NZ_CP073878
Organism Staphylococcus epidermidis strain B1285228

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV29_RS04330 Protein ID WP_002504557.1
Coordinates 822458..822853 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV29_RS04325 Protein ID WP_002504558.1
Coordinates 822228..822458 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV29_RS04260 (KFV29_04260) 817297..817779 + 483 WP_002504570.1 hypothetical protein -
KFV29_RS04265 (KFV29_04265) 817795..817974 + 180 WP_002504569.1 hypothetical protein -
KFV29_RS04270 (KFV29_04270) 817959..818144 + 186 WP_001187008.1 hypothetical protein -
KFV29_RS04275 (KFV29_04275) 818160..818444 + 285 WP_002504568.1 hypothetical protein -
KFV29_RS04280 (KFV29_04280) 818441..818596 + 156 WP_002504567.1 transcriptional activator RinB -
KFV29_RS04285 (KFV29_04285) 818622..818894 + 273 WP_002504566.1 hypothetical protein -
KFV29_RS04290 (KFV29_04290) 818910..819452 + 543 WP_002504565.1 hypothetical protein -
KFV29_RS04295 (KFV29_04295) 819445..819621 + 177 WP_002504564.1 hypothetical protein -
KFV29_RS04300 (KFV29_04300) 819641..819862 + 222 WP_002504563.1 hypothetical protein -
KFV29_RS04305 (KFV29_04305) 819862..820587 + 726 WP_010959229.1 metallophosphoesterase -
KFV29_RS04310 (KFV29_04310) 820580..820897 + 318 WP_002504561.1 hypothetical protein -
KFV29_RS04315 (KFV29_04315) 820897..821547 + 651 WP_002504560.1 hypothetical protein -
KFV29_RS04320 (KFV29_04320) 821547..822065 + 519 WP_002504559.1 metallophosphoesterase -
KFV29_RS04325 (KFV29_04325) 822228..822458 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV29_RS04330 (KFV29_04330) 822458..822853 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV29_RS04335 (KFV29_04335) 823216..823347 + 132 WP_257243913.1 hypothetical protein -
KFV29_RS04340 (KFV29_04340) 823331..823600 + 270 WP_000755772.1 hypothetical protein -
KFV29_RS04345 (KFV29_04345) 823657..824151 + 495 WP_010959224.1 hypothetical protein -
KFV29_RS04350 (KFV29_04350) 824155..824955 + 801 WP_000686449.1 metallophosphoesterase -
KFV29_RS04355 (KFV29_04355) 825064..825786 + 723 WP_002504538.1 hypothetical protein -
KFV29_RS04360 (KFV29_04360) 825892..826533 + 642 WP_002504537.1 hypothetical protein -
KFV29_RS13455 826564..826698 - 135 WP_002504536.1 hypothetical protein -
KFV29_RS04365 (KFV29_04365) 826781..827185 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721481..855531 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200449 WP_002504557.1 NZ_CP073878:822458-822853 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200449 NZ_CP097881:2290775-2292097 [Escherichia coli str. K-12 substr. MG1655]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200449 WP_002504558.1 NZ_CP073878:822228-822458 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200449 NZ_CP097881:2290509-2290775 [Escherichia coli str. K-12 substr. MG1655]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References