200374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 821131..821756 Replicon chromosome
Accession NZ_CP073840
Organism Staphylococcus epidermidis strain B1264454

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV39_RS04240 Protein ID WP_002504557.1
Coordinates 821361..821756 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV39_RS04235 Protein ID WP_002504558.1
Coordinates 821131..821361 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV39_RS04170 (KFV39_04170) 816200..816682 + 483 WP_002504570.1 hypothetical protein -
KFV39_RS04175 (KFV39_04175) 816698..816877 + 180 WP_002504569.1 hypothetical protein -
KFV39_RS04180 (KFV39_04180) 816862..817047 + 186 WP_001187008.1 hypothetical protein -
KFV39_RS04185 (KFV39_04185) 817063..817347 + 285 WP_002504568.1 hypothetical protein -
KFV39_RS04190 (KFV39_04190) 817344..817499 + 156 WP_002504567.1 transcriptional activator RinB -
KFV39_RS04195 (KFV39_04195) 817525..817797 + 273 WP_002504566.1 hypothetical protein -
KFV39_RS04200 (KFV39_04200) 817813..818355 + 543 WP_002504565.1 hypothetical protein -
KFV39_RS04205 (KFV39_04205) 818348..818524 + 177 WP_002504564.1 hypothetical protein -
KFV39_RS04210 (KFV39_04210) 818544..818765 + 222 WP_002504563.1 hypothetical protein -
KFV39_RS04215 (KFV39_04215) 818765..819490 + 726 WP_010959229.1 metallophosphoesterase -
KFV39_RS04220 (KFV39_04220) 819483..819800 + 318 WP_002504561.1 hypothetical protein -
KFV39_RS04225 (KFV39_04225) 819800..820450 + 651 WP_002504560.1 hypothetical protein -
KFV39_RS04230 (KFV39_04230) 820450..820968 + 519 WP_002504559.1 metallophosphoesterase -
KFV39_RS04235 (KFV39_04235) 821131..821361 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV39_RS04240 (KFV39_04240) 821361..821756 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV39_RS04245 (KFV39_04245) 822119..822250 + 132 WP_257243913.1 hypothetical protein -
KFV39_RS04250 (KFV39_04250) 822234..822503 + 270 WP_000755772.1 hypothetical protein -
KFV39_RS04255 (KFV39_04255) 822560..823054 + 495 WP_010959224.1 hypothetical protein -
KFV39_RS04260 (KFV39_04260) 823058..823858 + 801 WP_000686449.1 metallophosphoesterase -
KFV39_RS04265 (KFV39_04265) 823967..824689 + 723 WP_002504538.1 hypothetical protein -
KFV39_RS04270 (KFV39_04270) 824795..825436 + 642 WP_002504537.1 hypothetical protein -
KFV39_RS13300 825467..825601 - 135 WP_002504536.1 hypothetical protein -
KFV39_RS04275 (KFV39_04275) 825684..826088 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 720384..854434 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200374 WP_002504557.1 NZ_CP073840:821361-821756 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200374 NZ_CP097837:2081085-2081372 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200374 WP_002504558.1 NZ_CP073840:821131-821361 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200374 NZ_CP097837:2080846-2081085 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References