Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 895003..895628 Replicon chromosome
Accession NZ_CP093198
Organism Staphylococcus epidermidis strain TSM-18

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag MNU36_RS04225 Protein ID WP_002504557.1
Coordinates 895233..895628 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag MNU36_RS04220 Protein ID WP_002504558.1
Coordinates 895003..895233 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU36_RS04155 (MNU36_04155) 890072..890554 + 483 WP_002504570.1 hypothetical protein -
MNU36_RS04160 (MNU36_04160) 890570..890749 + 180 WP_002504569.1 hypothetical protein -
MNU36_RS04165 (MNU36_04165) 890734..890919 + 186 WP_001187008.1 hypothetical protein -
MNU36_RS04170 (MNU36_04170) 890935..891219 + 285 WP_002504568.1 hypothetical protein -
MNU36_RS04175 (MNU36_04175) 891216..891371 + 156 WP_002504567.1 transcriptional activator RinB -
MNU36_RS04180 (MNU36_04180) 891397..891669 + 273 WP_002504566.1 hypothetical protein -
MNU36_RS04185 (MNU36_04185) 891685..892227 + 543 WP_002504565.1 hypothetical protein -
MNU36_RS04190 (MNU36_04190) 892220..892396 + 177 WP_002504564.1 hypothetical protein -
MNU36_RS04195 (MNU36_04195) 892416..892637 + 222 WP_002504563.1 hypothetical protein -
MNU36_RS04200 (MNU36_04200) 892637..893362 + 726 WP_010959229.1 metallophosphoesterase -
MNU36_RS04205 (MNU36_04205) 893355..893672 + 318 WP_002504561.1 hypothetical protein -
MNU36_RS04210 (MNU36_04210) 893672..894322 + 651 WP_002504560.1 hypothetical protein -
MNU36_RS04215 (MNU36_04215) 894322..894840 + 519 WP_002504559.1 metallophosphoesterase -
MNU36_RS04220 (MNU36_04220) 895003..895233 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
MNU36_RS04225 (MNU36_04225) 895233..895628 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MNU36_RS04230 (MNU36_04230) 896106..896375 + 270 WP_000755772.1 hypothetical protein -
MNU36_RS04235 (MNU36_04235) 896432..896926 + 495 WP_010959224.1 hypothetical protein -
MNU36_RS04240 (MNU36_04240) 896930..897730 + 801 WP_000686449.1 metallophosphoesterase -
MNU36_RS04245 (MNU36_04245) 897839..898561 + 723 WP_002504538.1 hypothetical protein -
MNU36_RS04250 (MNU36_04250) 898667..899308 + 642 WP_002504537.1 hypothetical protein -
MNU36_RS04255 (MNU36_04255) 899556..899960 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 797336..927201 129865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T237782 WP_002504557.1 NZ_CP093198:895233-895628 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T237782 NZ_LR882944:c221288-221079 [Planktothrix agardhii]
GTGTTAGATCGGGTAGTTGAAGATGCTGACTACACCATAATTACCAGACGCGATGCTGATCATGCAGTAGTCATGTCCCT
TGATTATTTTAATGGTTTACTGGAAACGGTTCATTTATTAAAGTCGCCAGCCAACGCTGCTCATTTAGAACGTTCTATTG
CCCAATATAGGCAGGGGAAAGCTCTTGAACATCAGTTGATAGATGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT237782 WP_002504558.1 NZ_CP093198:895003-895233 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT237782 NZ_LR882944:c221086-220937 [Planktothrix agardhii]
ATGAGTAACCGCATATTAGCTTGGACTGACGAGGCTTGGGACAATTATATTTACTGGCAAAATCAGGATCGAAAAACTCT
CAAAAAAATTAATAAAATTATCAAAATCTGCCCACCTTACCCCTCTATTTCAAGAAAATTTATTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References