Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822265..822890 Replicon chromosome
Accession NZ_CP073821
Organism Staphylococcus epidermidis strain B1200343

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV43_RS04175 Protein ID WP_002504557.1
Coordinates 822495..822890 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV43_RS04170 Protein ID WP_002504558.1
Coordinates 822265..822495 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV43_RS04105 (KFV43_04105) 817334..817816 + 483 WP_002504570.1 hypothetical protein -
KFV43_RS04110 (KFV43_04110) 817832..818011 + 180 WP_002504569.1 hypothetical protein -
KFV43_RS04115 (KFV43_04115) 817996..818181 + 186 WP_001187008.1 hypothetical protein -
KFV43_RS04120 (KFV43_04120) 818197..818481 + 285 WP_002504568.1 hypothetical protein -
KFV43_RS04125 (KFV43_04125) 818478..818633 + 156 WP_002504567.1 transcriptional activator RinB -
KFV43_RS04130 (KFV43_04130) 818659..818931 + 273 WP_002504566.1 hypothetical protein -
KFV43_RS04135 (KFV43_04135) 818947..819489 + 543 WP_002504565.1 hypothetical protein -
KFV43_RS04140 (KFV43_04140) 819482..819658 + 177 WP_002504564.1 hypothetical protein -
KFV43_RS04145 (KFV43_04145) 819678..819899 + 222 WP_002504563.1 hypothetical protein -
KFV43_RS04150 (KFV43_04150) 819899..820624 + 726 WP_010959229.1 metallophosphoesterase -
KFV43_RS04155 (KFV43_04155) 820617..820934 + 318 WP_002504561.1 hypothetical protein -
KFV43_RS04160 (KFV43_04160) 820934..821584 + 651 WP_002504560.1 hypothetical protein -
KFV43_RS04165 (KFV43_04165) 821584..822102 + 519 WP_002504559.1 metallophosphoesterase -
KFV43_RS04170 (KFV43_04170) 822265..822495 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV43_RS04175 (KFV43_04175) 822495..822890 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV43_RS04180 (KFV43_04180) 823193..823384 + 192 WP_002504556.1 hypothetical protein -
KFV43_RS04185 (KFV43_04185) 823368..823637 + 270 WP_000755772.1 hypothetical protein -
KFV43_RS04190 (KFV43_04190) 823694..824188 + 495 WP_010959224.1 hypothetical protein -
KFV43_RS04195 (KFV43_04195) 824192..824992 + 801 WP_000686449.1 metallophosphoesterase -
KFV43_RS04200 (KFV43_04200) 825101..825823 + 723 WP_002504538.1 hypothetical protein -
KFV43_RS04205 (KFV43_04205) 825929..826570 + 642 WP_002504537.1 hypothetical protein -
KFV43_RS13365 826601..826735 - 135 WP_002504536.1 hypothetical protein -
KFV43_RS04210 (KFV43_04210) 826818..827222 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721518..855568 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200344 WP_002504557.1 NZ_CP073821:822495-822890 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200344 NZ_CP097832:c34260-33955 [Shigella flexneri]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200344 WP_002504558.1 NZ_CP073821:822265-822495 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200344 NZ_CP097832:c34480-34262 [Shigella flexneri]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References