Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1891625..1892250 Replicon chromosome
Accession NZ_CP073847
Organism Staphylococcus epidermidis strain B1266875

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV50_RS09020 Protein ID WP_002504557.1
Coordinates 1891625..1892020 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV50_RS09025 Protein ID WP_002504558.1
Coordinates 1892020..1892250 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV50_RS08985 (KFV50_08995) 1887293..1887697 + 405 WP_002504535.1 YolD-like family protein -
KFV50_RS13420 1887780..1887914 + 135 WP_002504536.1 hypothetical protein -
KFV50_RS08990 (KFV50_09000) 1887945..1888586 - 642 WP_002504537.1 hypothetical protein -
KFV50_RS08995 (KFV50_09005) 1888692..1889414 - 723 WP_002504538.1 hypothetical protein -
KFV50_RS09000 (KFV50_09010) 1889523..1890323 - 801 WP_000686449.1 metallophosphoesterase -
KFV50_RS09005 (KFV50_09015) 1890327..1890821 - 495 WP_010959224.1 hypothetical protein -
KFV50_RS09010 (KFV50_09020) 1890878..1891147 - 270 WP_000755772.1 hypothetical protein -
KFV50_RS09015 (KFV50_09025) 1891131..1891262 - 132 WP_257243913.1 hypothetical protein -
KFV50_RS09020 (KFV50_09030) 1891625..1892020 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV50_RS09025 (KFV50_09035) 1892020..1892250 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV50_RS09030 (KFV50_09040) 1892413..1892931 - 519 WP_002504559.1 metallophosphoesterase -
KFV50_RS09035 (KFV50_09045) 1892931..1893581 - 651 WP_002504560.1 hypothetical protein -
KFV50_RS09040 (KFV50_09050) 1893581..1893898 - 318 WP_002504561.1 hypothetical protein -
KFV50_RS09045 (KFV50_09055) 1893891..1894616 - 726 WP_010959229.1 metallophosphoesterase -
KFV50_RS09050 (KFV50_09060) 1894616..1894837 - 222 WP_002504563.1 hypothetical protein -
KFV50_RS09055 (KFV50_09065) 1894857..1895033 - 177 WP_002504564.1 hypothetical protein -
KFV50_RS09060 (KFV50_09070) 1895026..1895568 - 543 WP_002504565.1 hypothetical protein -
KFV50_RS09065 (KFV50_09075) 1895584..1895856 - 273 WP_002504566.1 hypothetical protein -
KFV50_RS09070 (KFV50_09080) 1895882..1896037 - 156 WP_002504567.1 transcriptional activator RinB -
KFV50_RS09075 (KFV50_09085) 1896034..1896318 - 285 WP_002504568.1 hypothetical protein -
KFV50_RS09080 (KFV50_09090) 1896334..1896519 - 186 WP_001187008.1 hypothetical protein -
KFV50_RS09085 (KFV50_09095) 1896504..1896683 - 180 WP_002504569.1 hypothetical protein -
KFV50_RS09090 (KFV50_09100) 1896699..1897181 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1857263..2000249 142986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200387 WP_002504557.1 NZ_CP073847:c1892020-1891625 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200387 NZ_CP097839:c197432-196950 [Shigella flexneri]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200387 WP_002504558.1 NZ_CP073847:c1892250-1892020 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200387 NZ_CP097839:c197725-197423 [Shigella flexneri]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References