Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1892913..1893538 Replicon chromosome
Accession NZ_CP073869
Organism Staphylococcus epidermidis strain B1279591

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV51_RS09100 Protein ID WP_002504557.1
Coordinates 1892913..1893308 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV51_RS09105 Protein ID WP_002504558.1
Coordinates 1893308..1893538 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV51_RS09065 (KFV51_09105) 1888581..1888985 + 405 WP_002504535.1 YolD-like family protein -
KFV51_RS13410 1889068..1889202 + 135 WP_002504536.1 hypothetical protein -
KFV51_RS09070 (KFV51_09110) 1889233..1889874 - 642 WP_002504537.1 hypothetical protein -
KFV51_RS09075 (KFV51_09115) 1889980..1890702 - 723 WP_002504538.1 hypothetical protein -
KFV51_RS09080 (KFV51_09120) 1890811..1891611 - 801 WP_000686449.1 metallophosphoesterase -
KFV51_RS09085 (KFV51_09125) 1891615..1892109 - 495 WP_010959224.1 hypothetical protein -
KFV51_RS09090 (KFV51_09130) 1892166..1892435 - 270 WP_000755772.1 hypothetical protein -
KFV51_RS09095 (KFV51_09135) 1892419..1892550 - 132 WP_257243913.1 hypothetical protein -
KFV51_RS09100 (KFV51_09140) 1892913..1893308 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV51_RS09105 (KFV51_09145) 1893308..1893538 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV51_RS09110 (KFV51_09150) 1893701..1894219 - 519 WP_002504559.1 metallophosphoesterase -
KFV51_RS09115 (KFV51_09155) 1894219..1894869 - 651 WP_002504560.1 hypothetical protein -
KFV51_RS09120 (KFV51_09160) 1894869..1895186 - 318 WP_002504561.1 hypothetical protein -
KFV51_RS09125 (KFV51_09165) 1895179..1895904 - 726 WP_010959229.1 metallophosphoesterase -
KFV51_RS09130 (KFV51_09170) 1895904..1896125 - 222 WP_002504563.1 hypothetical protein -
KFV51_RS09135 (KFV51_09175) 1896145..1896321 - 177 WP_002504564.1 hypothetical protein -
KFV51_RS09140 (KFV51_09180) 1896314..1896856 - 543 WP_002504565.1 hypothetical protein -
KFV51_RS09145 (KFV51_09185) 1896872..1897144 - 273 WP_002504566.1 hypothetical protein -
KFV51_RS09150 (KFV51_09190) 1897170..1897325 - 156 WP_002504567.1 transcriptional activator RinB -
KFV51_RS09155 (KFV51_09195) 1897322..1897606 - 285 WP_002504568.1 hypothetical protein -
KFV51_RS09160 (KFV51_09200) 1897622..1897807 - 186 WP_001187008.1 hypothetical protein -
KFV51_RS09165 (KFV51_09205) 1897792..1897971 - 180 WP_002504569.1 hypothetical protein -
KFV51_RS09170 (KFV51_09210) 1897987..1898469 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1861341..1994285 132944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200432 WP_002504557.1 NZ_CP073869:c1893308-1892913 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200432 NZ_CP097870:3706243-3706524 [Thauera sp. GDN1]
ATGTCAATCCTGAGCTTCCGCTGTCCTCTTTCCGCAGCACTGTTTGCACGGGAACGTGTTGCACGCTTCGCCAATATTGA
GGCGAGCGCTCGCCGAAAGCTGGTATTGCTGGACGCGGCAAAGGATCTCAAGGATCTACGCATTCCGCCAGGAAACCGGC
TTGAGGCTTTGTCGGGTAATCGGGCGGGGCAACACAGCATTCGCATCAACGACCAGTGGCGCGTGTGTTTCCGCTGGACG
GCAGATGGGGCTGAGGACGTCGAGATTGTCGATTACCACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200432 WP_002504558.1 NZ_CP073869:c1893538-1893308 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200432 NZ_CP097870:3706537-3706836 [Thauera sp. GDN1]
ATGAGCGAGAAGCTTGCCCCCATGCACCCGGGCGAAGTGCTGCGCGAGGAGTTCATGGTACCGCTCGGGCTCTCCAGCAA
TGCGCTTGCGCGTGCGCTGGGGGTGACCGCGGCGCGGATCAACGAGATCGTTCGTGAAGAGCGCGGCATTACGGCCGACA
CAGCGCTGCGCTTGGCCCGCTACTTCGGCACGTCGGAAGACCTTTGGCTGAACCTGCAGCGGCGCTACGACGTCGAGCGC
GCACGCGATGCGCTTGGCGCTTCGCTGGAAGCGATCGTGCCGATGCGGGAAGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References