Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822264..822889 Replicon chromosome
Accession NZ_CP073900
Organism Staphylococcus epidermidis strain V1949610

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV25_RS04165 Protein ID WP_002504557.1
Coordinates 822494..822889 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV25_RS04160 Protein ID WP_002504558.1
Coordinates 822264..822494 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV25_RS04095 (KFV25_04095) 817333..817815 + 483 WP_002504570.1 hypothetical protein -
KFV25_RS04100 (KFV25_04100) 817831..818010 + 180 WP_002504569.1 hypothetical protein -
KFV25_RS04105 (KFV25_04105) 817995..818180 + 186 WP_001187008.1 hypothetical protein -
KFV25_RS04110 (KFV25_04110) 818196..818480 + 285 WP_002504568.1 hypothetical protein -
KFV25_RS04115 (KFV25_04115) 818477..818632 + 156 WP_002504567.1 transcriptional activator RinB -
KFV25_RS04120 (KFV25_04120) 818658..818930 + 273 WP_002504566.1 hypothetical protein -
KFV25_RS04125 (KFV25_04125) 818946..819488 + 543 WP_002504565.1 hypothetical protein -
KFV25_RS04130 (KFV25_04130) 819481..819657 + 177 WP_002504564.1 hypothetical protein -
KFV25_RS04135 (KFV25_04135) 819677..819898 + 222 WP_002504563.1 hypothetical protein -
KFV25_RS04140 (KFV25_04140) 819898..820623 + 726 WP_010959229.1 metallophosphoesterase -
KFV25_RS04145 (KFV25_04145) 820616..820933 + 318 WP_002504561.1 hypothetical protein -
KFV25_RS04150 (KFV25_04150) 820933..821583 + 651 WP_002504560.1 hypothetical protein -
KFV25_RS04155 (KFV25_04155) 821583..822101 + 519 WP_002504559.1 metallophosphoesterase -
KFV25_RS04160 (KFV25_04160) 822264..822494 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV25_RS04165 (KFV25_04165) 822494..822889 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV25_RS04170 (KFV25_04170) 823252..823383 + 132 WP_257243913.1 hypothetical protein -
KFV25_RS04175 (KFV25_04175) 823367..823636 + 270 WP_000755772.1 hypothetical protein -
KFV25_RS04180 (KFV25_04180) 823693..824187 + 495 WP_010959224.1 hypothetical protein -
KFV25_RS04185 (KFV25_04185) 824191..824991 + 801 WP_000686449.1 metallophosphoesterase -
KFV25_RS04190 (KFV25_04190) 825100..825822 + 723 WP_002504538.1 hypothetical protein -
KFV25_RS04195 (KFV25_04195) 825928..826569 + 642 WP_002504537.1 hypothetical protein -
KFV25_RS13330 826600..826734 - 135 WP_002504536.1 hypothetical protein -
KFV25_RS04200 (KFV25_04200) 826817..827221 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721517..855567 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200489 WP_002504557.1 NZ_CP073900:822494-822889 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200489 NZ_CP097883:c606394-605930 [Escherichia coli str. K-12 substr. MG1655]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200489 WP_002504558.1 NZ_CP073900:822264-822494 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200489 NZ_CP097883:c606729-606394 [Escherichia coli str. K-12 substr. MG1655]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References