Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1957607..1958232 Replicon chromosome
Accession NZ_CP073898
Organism Staphylococcus epidermidis strain V1939586

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV32_RS09355 Protein ID WP_002504557.1
Coordinates 1957607..1958002 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV32_RS09360 Protein ID WP_002504558.1
Coordinates 1958002..1958232 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV32_RS09320 (KFV32_09330) 1953275..1953679 + 405 WP_002504535.1 YolD-like family protein -
KFV32_RS13370 1953762..1953896 + 135 WP_002504536.1 hypothetical protein -
KFV32_RS09325 (KFV32_09335) 1953927..1954568 - 642 WP_002504537.1 hypothetical protein -
KFV32_RS09330 (KFV32_09340) 1954674..1955396 - 723 WP_002504538.1 hypothetical protein -
KFV32_RS09335 (KFV32_09345) 1955505..1956305 - 801 WP_000686449.1 metallophosphoesterase -
KFV32_RS09340 (KFV32_09350) 1956309..1956803 - 495 WP_010959224.1 hypothetical protein -
KFV32_RS09345 (KFV32_09355) 1956860..1957129 - 270 WP_000755772.1 hypothetical protein -
KFV32_RS09350 (KFV32_09360) 1957113..1957244 - 132 WP_257243913.1 hypothetical protein -
KFV32_RS09355 (KFV32_09365) 1957607..1958002 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV32_RS09360 (KFV32_09370) 1958002..1958232 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV32_RS09365 (KFV32_09375) 1958395..1958913 - 519 WP_002504559.1 metallophosphoesterase -
KFV32_RS09370 (KFV32_09380) 1958913..1959563 - 651 WP_002504560.1 hypothetical protein -
KFV32_RS09375 (KFV32_09385) 1959563..1959880 - 318 WP_002504561.1 hypothetical protein -
KFV32_RS09380 (KFV32_09390) 1959873..1960598 - 726 WP_010959229.1 metallophosphoesterase -
KFV32_RS09385 (KFV32_09395) 1960598..1960819 - 222 WP_002504563.1 hypothetical protein -
KFV32_RS09390 (KFV32_09400) 1960839..1961015 - 177 WP_002504564.1 hypothetical protein -
KFV32_RS09395 (KFV32_09405) 1961008..1961550 - 543 WP_002504565.1 hypothetical protein -
KFV32_RS09400 (KFV32_09410) 1961566..1961838 - 273 WP_002504566.1 hypothetical protein -
KFV32_RS09405 (KFV32_09415) 1961864..1962019 - 156 WP_002504567.1 transcriptional activator RinB -
KFV32_RS09410 (KFV32_09420) 1962016..1962300 - 285 WP_002504568.1 hypothetical protein -
KFV32_RS09415 (KFV32_09425) 1962316..1962501 - 186 WP_001187008.1 hypothetical protein -
KFV32_RS09420 (KFV32_09430) 1962486..1962665 - 180 WP_002504569.1 hypothetical protein -
KFV32_RS09425 (KFV32_09435) 1962681..1963163 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1923245..2058979 135734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200482 WP_002504557.1 NZ_CP073898:c1958002-1957607 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200482 NZ_CP097882:c3663742-3663344 [Escherichia coli str. K-12 substr. MG1655]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200482 WP_002504558.1 NZ_CP073898:c1958232-1958002 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200482 NZ_CP097882:c3664038-3663745 [Escherichia coli str. K-12 substr. MG1655]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References