200417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1890554..1891179 Replicon chromosome
Accession NZ_CP073862
Organism Staphylococcus epidermidis strain B1276219

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV45_RS09115 Protein ID WP_002504557.1
Coordinates 1890554..1890949 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV45_RS09120 Protein ID WP_002504558.1
Coordinates 1890949..1891179 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV45_RS09080 (KFV45_09090) 1886222..1886626 + 405 WP_002504535.1 YolD-like family protein -
KFV45_RS13405 1886709..1886843 + 135 WP_002504536.1 hypothetical protein -
KFV45_RS09085 (KFV45_09095) 1886874..1887515 - 642 WP_002504537.1 hypothetical protein -
KFV45_RS09090 (KFV45_09100) 1887621..1888343 - 723 WP_002504538.1 hypothetical protein -
KFV45_RS09095 (KFV45_09105) 1888452..1889252 - 801 WP_000686449.1 metallophosphoesterase -
KFV45_RS09100 (KFV45_09110) 1889256..1889750 - 495 WP_010959224.1 hypothetical protein -
KFV45_RS09105 (KFV45_09115) 1889807..1890076 - 270 WP_000755772.1 hypothetical protein -
KFV45_RS09110 (KFV45_09120) 1890060..1890251 - 192 WP_002504556.1 hypothetical protein -
KFV45_RS09115 (KFV45_09125) 1890554..1890949 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV45_RS09120 (KFV45_09130) 1890949..1891179 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV45_RS09125 (KFV45_09135) 1891342..1891860 - 519 WP_002504559.1 metallophosphoesterase -
KFV45_RS09130 (KFV45_09140) 1891860..1892510 - 651 WP_002504560.1 hypothetical protein -
KFV45_RS09135 (KFV45_09145) 1892510..1892827 - 318 WP_002504561.1 hypothetical protein -
KFV45_RS09140 (KFV45_09150) 1892820..1893545 - 726 WP_010959229.1 metallophosphoesterase -
KFV45_RS09145 (KFV45_09155) 1893545..1893766 - 222 WP_002504563.1 hypothetical protein -
KFV45_RS09150 (KFV45_09160) 1893786..1893962 - 177 WP_002504564.1 hypothetical protein -
KFV45_RS09155 (KFV45_09165) 1893955..1894497 - 543 WP_002504565.1 hypothetical protein -
KFV45_RS09160 (KFV45_09170) 1894513..1894785 - 273 WP_002504566.1 hypothetical protein -
KFV45_RS09165 (KFV45_09175) 1894811..1894966 - 156 WP_002504567.1 transcriptional activator RinB -
KFV45_RS09170 (KFV45_09180) 1894963..1895247 - 285 WP_002504568.1 hypothetical protein -
KFV45_RS09175 (KFV45_09185) 1895263..1895448 - 186 WP_001187008.1 hypothetical protein -
KFV45_RS09180 (KFV45_09190) 1895433..1895612 - 180 WP_002504569.1 hypothetical protein -
KFV45_RS09185 (KFV45_09195) 1895628..1896110 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1856192..1991926 135734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200417 WP_002504557.1 NZ_CP073862:c1890949-1890554 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200417 NZ_CP097857:2918367-2918945 [Pseudomonas sp. B111]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTTTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCACTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGATAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200417 WP_002504558.1 NZ_CP073862:c1891179-1890949 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200417 NZ_CP097857:2917724-2918278 [Pseudomonas sp. B111]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCATCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACAAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGACGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGATGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References