Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1750553..1751178 Replicon chromosome
Accession NZ_CP093181
Organism Staphylococcus epidermidis strain TMDU-265

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag MNU40_RS08660 Protein ID WP_002504557.1
Coordinates 1750553..1750948 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag MNU40_RS08665 Protein ID WP_002504558.1
Coordinates 1750948..1751178 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU40_RS08630 (MNU40_08635) 1746221..1746625 + 405 WP_002504535.1 YolD-like family protein -
MNU40_RS08635 (MNU40_08640) 1746873..1747514 - 642 WP_002504537.1 hypothetical protein -
MNU40_RS08640 (MNU40_08645) 1747620..1748342 - 723 WP_002504538.1 hypothetical protein -
MNU40_RS08645 (MNU40_08650) 1748451..1749251 - 801 WP_000686449.1 metallophosphoesterase -
MNU40_RS08650 (MNU40_08655) 1749255..1749749 - 495 WP_010959224.1 hypothetical protein -
MNU40_RS08655 (MNU40_08660) 1749806..1750075 - 270 WP_000755772.1 hypothetical protein -
MNU40_RS08660 (MNU40_08665) 1750553..1750948 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MNU40_RS08665 (MNU40_08670) 1750948..1751178 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
MNU40_RS08670 (MNU40_08675) 1751341..1751859 - 519 WP_002504559.1 metallophosphoesterase -
MNU40_RS08675 (MNU40_08680) 1751859..1752509 - 651 WP_002504560.1 hypothetical protein -
MNU40_RS08680 (MNU40_08685) 1752509..1752826 - 318 WP_002504561.1 hypothetical protein -
MNU40_RS08685 (MNU40_08690) 1752819..1753544 - 726 WP_010959229.1 metallophosphoesterase -
MNU40_RS08690 (MNU40_08695) 1753544..1753765 - 222 WP_002504563.1 hypothetical protein -
MNU40_RS08695 (MNU40_08700) 1753785..1753961 - 177 WP_002504564.1 hypothetical protein -
MNU40_RS08700 (MNU40_08705) 1753954..1754496 - 543 WP_002504565.1 hypothetical protein -
MNU40_RS08705 (MNU40_08710) 1754512..1754784 - 273 WP_002504566.1 hypothetical protein -
MNU40_RS08710 (MNU40_08715) 1754810..1754965 - 156 WP_002504567.1 transcriptional activator RinB -
MNU40_RS08715 (MNU40_08720) 1754962..1755246 - 285 WP_002504568.1 hypothetical protein -
MNU40_RS08720 (MNU40_08725) 1755262..1755447 - 186 WP_001187008.1 hypothetical protein -
MNU40_RS08725 (MNU40_08730) 1755432..1755611 - 180 WP_002504569.1 hypothetical protein -
MNU40_RS08730 (MNU40_08735) 1755627..1756109 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1717874..1851470 133596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T237760 WP_002504557.1 NZ_CP093181:c1750948-1750553 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T237760 NZ_LR882500:c3133992-3133108 [Mycobacterium tuberculosis variant microti]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT237760 WP_002504558.1 NZ_CP093181:c1751178-1750948 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT237760 NZ_LR882500:c3134882-3133995 [Mycobacterium tuberculosis variant microti]
GTGGTGAGCCCAGCCGGCGCCGATCGGCGCATCCCCACGTGGGCGTCACGGGTGGTGTCCGGCCTCGCTCGCGATCGGCC
CGTAGTCGTCACGAAAGAGGATCTGACGCAACGGCTTACAGAGGCTGGGTGTGGACGCGACCCCGACTCCGCCATCCGCG
AACTGCGCCGCATTGGGTGGCTGGTCCAACTGCCGGTGAAAGGCACCTGGGCATTCATTCCCCCCGGCGAGGCCGCCATC
TCGGACCCGTATCTACCGCTGCGCTCGTGGCTGGCCCGTGACCAGAACGCGGGCTTCATGCTGGCCGGTGCATCCGCAGC
GTGGCACCTCGGATACCTGGACCGCCAACCCGACGGCCGCATCCCGATCTGGCTGCCGCCGGCCAAAAGGCTGCCCGACG
GCCTAGCATCGTATGTGTCCGTCGTGCGCATCCCCTGGAACGCGGCGGACACCGCACTGCTGGCTCCGCGTCCCGCGTTG
CTGGTCCGGCGGCGGCTCGACCTCGTCGCGTGGGCGACCGGGTTACCGGCGCTAGGACCAGAAGCATTACTTGTGCAAAT
CGCCACGCGCCCGGCCTCGTTCGGGCCGTGGGCCGACCTTGTCCCCCACCTTGACGACCTCGTCGCCGACTGCAGTGACG
AGCGTCTGGAGCGTCTACTGTCGGGCCGGCCGACATCGGCCTGGCAGCGTGCAAGCTACCTGCTGGACTCGGGCGGTGAA
CCGGCACGAGGCCAGGCGCTGCTGGCCAAGCGGCACACCGAAGTGATGCCGGTGACTCGATTCACCACCGCGCACAGCCG
CGACCGTGGCGAGAGTGTCTGGGCTCCCGAGTATCAGCTTGTCGACGAGCTCGTCGTACCGCTGCTGCGCGTGATCGGCA
AGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References