200412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1893071..1893696 Replicon chromosome
Accession NZ_CP073859
Organism Staphylococcus epidermidis strain B1275857

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV44_RS09055 Protein ID WP_002504557.1
Coordinates 1893071..1893466 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV44_RS09060 Protein ID WP_002504558.1
Coordinates 1893466..1893696 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV44_RS09020 (KFV44_09030) 1888739..1889143 + 405 WP_002504535.1 YolD-like family protein -
KFV44_RS13415 1889226..1889360 + 135 WP_002504536.1 hypothetical protein -
KFV44_RS09025 (KFV44_09035) 1889391..1890032 - 642 WP_002504537.1 hypothetical protein -
KFV44_RS09030 (KFV44_09040) 1890138..1890860 - 723 WP_002504538.1 hypothetical protein -
KFV44_RS09035 (KFV44_09045) 1890969..1891769 - 801 WP_000686449.1 metallophosphoesterase -
KFV44_RS09040 (KFV44_09050) 1891773..1892267 - 495 WP_010959224.1 hypothetical protein -
KFV44_RS09045 (KFV44_09055) 1892324..1892593 - 270 WP_000755772.1 hypothetical protein -
KFV44_RS09050 (KFV44_09060) 1892577..1892768 - 192 WP_002504556.1 hypothetical protein -
KFV44_RS09055 (KFV44_09065) 1893071..1893466 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV44_RS09060 (KFV44_09070) 1893466..1893696 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV44_RS09065 (KFV44_09075) 1893859..1894377 - 519 WP_002504559.1 metallophosphoesterase -
KFV44_RS09070 (KFV44_09080) 1894377..1895027 - 651 WP_002504560.1 hypothetical protein -
KFV44_RS09075 (KFV44_09085) 1895027..1895344 - 318 WP_002504561.1 hypothetical protein -
KFV44_RS09080 (KFV44_09090) 1895337..1896062 - 726 WP_010959229.1 metallophosphoesterase -
KFV44_RS09085 (KFV44_09095) 1896062..1896283 - 222 WP_002504563.1 hypothetical protein -
KFV44_RS09090 (KFV44_09100) 1896303..1896479 - 177 WP_002504564.1 hypothetical protein -
KFV44_RS09095 (KFV44_09105) 1896472..1897014 - 543 WP_002504565.1 hypothetical protein -
KFV44_RS09100 (KFV44_09110) 1897030..1897302 - 273 WP_002504566.1 hypothetical protein -
KFV44_RS09105 (KFV44_09115) 1897328..1897483 - 156 WP_002504567.1 transcriptional activator RinB -
KFV44_RS09110 (KFV44_09120) 1897480..1897764 - 285 WP_002504568.1 hypothetical protein -
KFV44_RS09115 (KFV44_09125) 1897780..1897965 - 186 WP_001187008.1 hypothetical protein -
KFV44_RS09120 (KFV44_09130) 1897950..1898129 - 180 WP_002504569.1 hypothetical protein -
KFV44_RS09125 (KFV44_09135) 1898145..1898627 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1861499..1994443 132944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200412 WP_002504557.1 NZ_CP073859:c1893466-1893071 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200412 NZ_CP097846:1218607-1218789 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200412 WP_002504558.1 NZ_CP073859:c1893696-1893466 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200412 NZ_CP097846:1218891-1219292 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References