20629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1599342..1599967 Replicon chromosome
Accession NC_002976
Organism Staphylococcus epidermidis RP62A

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag SERP_RS07785 Protein ID WP_002504557.1
Coordinates 1599342..1599737 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag SERP_RS07790 Protein ID WP_002504558.1
Coordinates 1599737..1599967 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERP_RS07750 1595010..1595414 + 405 WP_002504535.1 YolD-like family protein -
SERP_RS07755 1595662..1596303 - 642 WP_002504537.1 hypothetical protein -
SERP_RS07760 1596409..1597131 - 723 WP_002504538.1 hypothetical protein -
SERP_RS07765 1597240..1598040 - 801 WP_000686449.1 metallophosphoesterase -
SERP_RS07770 1598044..1598538 - 495 WP_010959224.1 hypothetical protein -
SERP_RS07775 1598595..1598864 - 270 WP_000755772.1 hypothetical protein -
SERP_RS07780 1598848..1599039 - 192 WP_002504556.1 hypothetical protein -
SERP_RS07785 1599342..1599737 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
SERP_RS07790 1599737..1599967 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
SERP_RS07795 1600130..1600648 - 519 WP_002504559.1 metallophosphoesterase -
SERP_RS07800 1600648..1601298 - 651 WP_002504560.1 hypothetical protein -
SERP_RS07805 1601298..1601615 - 318 WP_002504561.1 hypothetical protein -
SERP_RS07810 1601608..1602333 - 726 WP_010959229.1 metallophosphoesterase -
SERP_RS07815 1602333..1602554 - 222 WP_002504563.1 hypothetical protein -
SERP_RS14010 1602574..1602750 - 177 WP_002504564.1 hypothetical protein -
SERP_RS07820 1602743..1603285 - 543 WP_002504565.1 hypothetical protein -
SERP_RS07825 1603301..1603573 - 273 WP_002504566.1 hypothetical protein -
SERP_RS07830 1603599..1603754 - 156 WP_002504567.1 transcriptional activator RinB -
SERP_RS07835 1603751..1604035 - 285 WP_002504568.1 hypothetical protein -
SERP_RS07840 1604051..1604236 - 186 WP_001187008.1 hypothetical protein -
SERP_RS07845 1604221..1604400 - 180 WP_002504569.1 hypothetical protein -
SERP_RS07850 1604416..1604898 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1566662..1694824 128162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T20629 WP_002504557.1 NC_002976:c1599737-1599342 [Staphylococcus epidermidis RP62A]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T20629 NC_002976:c1599737-1599342 [Staphylococcus epidermidis RP62A]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT20629 WP_002504558.1 NC_002976:c1599967-1599737 [Staphylococcus epidermidis RP62A]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT20629 NC_002976:c1599967-1599737 [Staphylococcus epidermidis RP62A]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References