142254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 994797..995422 Replicon chromosome
Accession NZ_CP045648
Organism Staphylococcus epidermidis strain IRL01

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag GFV05_RS04890 Protein ID WP_002504557.1
Coordinates 995027..995422 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag GFV05_RS04885 Protein ID WP_002504558.1
Coordinates 994797..995027 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFV05_RS04825 989866..990348 + 483 WP_002504570.1 hypothetical protein -
GFV05_RS04830 990364..990543 + 180 WP_002504569.1 hypothetical protein -
GFV05_RS04835 990528..990713 + 186 WP_001187008.1 hypothetical protein -
GFV05_RS04840 990729..991013 + 285 WP_002504568.1 hypothetical protein -
GFV05_RS04845 991010..991165 + 156 WP_002504567.1 transcriptional activator RinB -
GFV05_RS04850 991191..991463 + 273 WP_002504566.1 hypothetical protein -
GFV05_RS04855 991479..992021 + 543 WP_002504565.1 hypothetical protein -
GFV05_RS13850 992014..992190 + 177 WP_002504564.1 hypothetical protein -
GFV05_RS04860 992210..992431 + 222 WP_002504563.1 hypothetical protein -
GFV05_RS04865 992431..993156 + 726 WP_010959229.1 metallophosphoesterase -
GFV05_RS04870 993149..993466 + 318 WP_002504561.1 hypothetical protein -
GFV05_RS04875 993466..994116 + 651 WP_002504560.1 hypothetical protein -
GFV05_RS04880 994116..994634 + 519 WP_002504559.1 metallophosphoesterase -
GFV05_RS04885 994797..995027 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
GFV05_RS04890 995027..995422 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GFV05_RS04895 995725..995916 + 192 WP_002504556.1 hypothetical protein -
GFV05_RS04900 995900..996169 + 270 WP_000755772.1 hypothetical protein -
GFV05_RS04905 996226..996720 + 495 WP_010959224.1 hypothetical protein -
GFV05_RS04910 996724..997524 + 801 WP_000686449.1 metallophosphoesterase -
GFV05_RS04915 997633..998355 + 723 WP_002504538.1 hypothetical protein -
GFV05_RS04920 998461..999102 + 642 WP_002504537.1 hypothetical protein -
GFV05_RS04925 999350..999754 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 895918..1026995 131077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T142254 WP_002504557.1 NZ_CP045648:995027-995422 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T142254 NZ_CP060509:c14054-13704 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT142254 WP_002504558.1 NZ_CP045648:994797-995027 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT142254 NZ_CP060509:c13699-13397 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References