200349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 819708..820333 Replicon chromosome
Accession NZ_CP073824
Organism Staphylococcus epidermidis strain B1200599

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV28_RS04165 Protein ID WP_002504557.1
Coordinates 819938..820333 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV28_RS04160 Protein ID WP_002504558.1
Coordinates 819708..819938 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV28_RS04095 (KFV28_04095) 814777..815259 + 483 WP_002504570.1 hypothetical protein -
KFV28_RS04100 (KFV28_04100) 815275..815454 + 180 WP_002504569.1 hypothetical protein -
KFV28_RS04105 (KFV28_04105) 815439..815624 + 186 WP_001187008.1 hypothetical protein -
KFV28_RS04110 (KFV28_04110) 815640..815924 + 285 WP_002504568.1 hypothetical protein -
KFV28_RS04115 (KFV28_04115) 815921..816076 + 156 WP_002504567.1 transcriptional activator RinB -
KFV28_RS04120 (KFV28_04120) 816102..816374 + 273 WP_002504566.1 hypothetical protein -
KFV28_RS04125 (KFV28_04125) 816390..816932 + 543 WP_002504565.1 hypothetical protein -
KFV28_RS04130 (KFV28_04130) 816925..817101 + 177 WP_002504564.1 hypothetical protein -
KFV28_RS04135 (KFV28_04135) 817121..817342 + 222 WP_002504563.1 hypothetical protein -
KFV28_RS04140 (KFV28_04140) 817342..818067 + 726 WP_010959229.1 metallophosphoesterase -
KFV28_RS04145 (KFV28_04145) 818060..818377 + 318 WP_002504561.1 hypothetical protein -
KFV28_RS04150 (KFV28_04150) 818377..819027 + 651 WP_002504560.1 hypothetical protein -
KFV28_RS04155 (KFV28_04155) 819027..819545 + 519 WP_002504559.1 metallophosphoesterase -
KFV28_RS04160 (KFV28_04160) 819708..819938 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV28_RS04165 (KFV28_04165) 819938..820333 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV28_RS04170 (KFV28_04170) 820636..820827 + 192 WP_002504556.1 hypothetical protein -
KFV28_RS04175 (KFV28_04175) 820811..821080 + 270 WP_000755772.1 hypothetical protein -
KFV28_RS04180 (KFV28_04180) 821137..821631 + 495 WP_010959224.1 hypothetical protein -
KFV28_RS04185 (KFV28_04185) 821635..822435 + 801 WP_000686449.1 metallophosphoesterase -
KFV28_RS04190 (KFV28_04190) 822544..823266 + 723 WP_002504538.1 hypothetical protein -
KFV28_RS04195 (KFV28_04195) 823372..824013 + 642 WP_002504537.1 hypothetical protein -
KFV28_RS13350 824044..824178 - 135 WP_002504536.1 hypothetical protein -
KFV28_RS04200 (KFV28_04200) 824261..824665 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 718961..853011 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200349 WP_002504557.1 NZ_CP073824:819938-820333 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200349 NZ_CP097834:861224-861327 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200349 WP_002504558.1 NZ_CP073824:819708-819938 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200349 NZ_CP097834:c861328-861094 [Shigella flexneri]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGCTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References