Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1017694..1018319 Replicon chromosome
Accession NZ_LR735432
Organism Staphylococcus epidermidis strain none isolate Se_RP62a-WT

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag GOZ24_RS04945 Protein ID WP_002504557.1
Coordinates 1017924..1018319 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag GOZ24_RS04940 Protein ID WP_002504558.1
Coordinates 1017694..1017924 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ24_RS04880 1012763..1013245 + 483 WP_002504570.1 hypothetical protein -
GOZ24_RS04885 1013261..1013440 + 180 WP_002504569.1 hypothetical protein -
GOZ24_RS04890 1013425..1013610 + 186 WP_001187008.1 hypothetical protein -
GOZ24_RS04895 1013626..1013910 + 285 WP_002504568.1 hypothetical protein -
GOZ24_RS04900 1013907..1014062 + 156 WP_002504567.1 transcriptional activator RinB -
GOZ24_RS04905 1014088..1014360 + 273 WP_002504566.1 hypothetical protein -
GOZ24_RS04910 1014376..1014918 + 543 WP_002504565.1 hypothetical protein -
GOZ24_RS13105 1014911..1015087 + 177 WP_002504564.1 hypothetical protein -
GOZ24_RS04915 1015107..1015328 + 222 WP_002504563.1 hypothetical protein -
GOZ24_RS04920 1015328..1016053 + 726 WP_010959229.1 metallophosphoesterase -
GOZ24_RS04925 1016046..1016363 + 318 WP_002504561.1 hypothetical protein -
GOZ24_RS04930 1016363..1017013 + 651 WP_002504560.1 hypothetical protein -
GOZ24_RS04935 1017013..1017531 + 519 WP_002504559.1 metallophosphoesterase -
GOZ24_RS04940 1017694..1017924 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
GOZ24_RS04945 1017924..1018319 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GOZ24_RS04950 1018622..1018813 + 192 WP_002504556.1 hypothetical protein -
GOZ24_RS04955 1018797..1019066 + 270 WP_000755772.1 hypothetical protein -
GOZ24_RS04960 1019123..1019617 + 495 WP_010959224.1 hypothetical protein -
GOZ24_RS04965 1019621..1020421 + 801 WP_000686449.1 metallophosphoesterase -
GOZ24_RS04970 1020530..1021252 + 723 WP_002504538.1 hypothetical protein -
GOZ24_RS04975 1021358..1021999 + 642 WP_002504537.1 hypothetical protein -
GOZ24_RS04980 1022247..1022651 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') groEL 919774..1065570 145796


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T288880 WP_002504557.1 NZ_LR735432:1017924-1018319 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T288880 NZ_LR735432:1017924-1018319 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT288880 WP_002504558.1 NZ_LR735432:1017694-1017924 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT288880 NZ_LR735432:1017694-1017924 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References