200384

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822167..822792 Replicon chromosome
Accession NZ_CP073844
Organism Staphylococcus epidermidis strain B1265603

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV41_RS04170 Protein ID WP_002504557.1
Coordinates 822397..822792 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV41_RS04165 Protein ID WP_002504558.1
Coordinates 822167..822397 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV41_RS04100 (KFV41_04100) 817236..817718 + 483 WP_002504570.1 hypothetical protein -
KFV41_RS04105 (KFV41_04105) 817734..817913 + 180 WP_002504569.1 hypothetical protein -
KFV41_RS04110 (KFV41_04110) 817898..818083 + 186 WP_001187008.1 hypothetical protein -
KFV41_RS04115 (KFV41_04115) 818099..818383 + 285 WP_002504568.1 hypothetical protein -
KFV41_RS04120 (KFV41_04120) 818380..818535 + 156 WP_002504567.1 transcriptional activator RinB -
KFV41_RS04125 (KFV41_04125) 818561..818833 + 273 WP_002504566.1 hypothetical protein -
KFV41_RS04130 (KFV41_04130) 818849..819391 + 543 WP_002504565.1 hypothetical protein -
KFV41_RS04135 (KFV41_04135) 819384..819560 + 177 WP_002504564.1 hypothetical protein -
KFV41_RS04140 (KFV41_04140) 819580..819801 + 222 WP_002504563.1 hypothetical protein -
KFV41_RS04145 (KFV41_04145) 819801..820526 + 726 WP_010959229.1 metallophosphoesterase -
KFV41_RS04150 (KFV41_04150) 820519..820836 + 318 WP_002504561.1 hypothetical protein -
KFV41_RS04155 (KFV41_04155) 820836..821486 + 651 WP_002504560.1 hypothetical protein -
KFV41_RS04160 (KFV41_04160) 821486..822004 + 519 WP_002504559.1 metallophosphoesterase -
KFV41_RS04165 (KFV41_04165) 822167..822397 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV41_RS04170 (KFV41_04170) 822397..822792 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV41_RS04175 (KFV41_04175) 823095..823286 + 192 WP_002504556.1 hypothetical protein -
KFV41_RS04180 (KFV41_04180) 823270..823539 + 270 WP_000755772.1 hypothetical protein -
KFV41_RS04185 (KFV41_04185) 823596..824090 + 495 WP_010959224.1 hypothetical protein -
KFV41_RS04190 (KFV41_04190) 824094..824894 + 801 WP_000686449.1 metallophosphoesterase -
KFV41_RS04195 (KFV41_04195) 825003..825725 + 723 WP_002504538.1 hypothetical protein -
KFV41_RS04200 (KFV41_04200) 825831..826472 + 642 WP_002504537.1 hypothetical protein -
KFV41_RS13360 826503..826637 - 135 WP_002504536.1 hypothetical protein -
KFV41_RS04205 (KFV41_04205) 826720..827124 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721420..859975 138555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200384 WP_002504557.1 NZ_CP073844:822397-822792 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200384 NZ_CP097839:110004-110279 [Shigella flexneri]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200384 WP_002504558.1 NZ_CP073844:822167-822397 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200384 NZ_CP097839:109720-110004 [Shigella flexneri]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGTCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References