Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822360..822985 Replicon chromosome
Accession NZ_CP073836
Organism Staphylococcus epidermidis strain B1262351

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV42_RS04170 Protein ID WP_002504557.1
Coordinates 822590..822985 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV42_RS04165 Protein ID WP_002504558.1
Coordinates 822360..822590 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV42_RS04100 (KFV42_04100) 817429..817911 + 483 WP_002504570.1 hypothetical protein -
KFV42_RS04105 (KFV42_04105) 817927..818106 + 180 WP_002504569.1 hypothetical protein -
KFV42_RS04110 (KFV42_04110) 818091..818276 + 186 WP_001187008.1 hypothetical protein -
KFV42_RS04115 (KFV42_04115) 818292..818576 + 285 WP_002504568.1 hypothetical protein -
KFV42_RS04120 (KFV42_04120) 818573..818728 + 156 WP_002504567.1 transcriptional activator RinB -
KFV42_RS04125 (KFV42_04125) 818754..819026 + 273 WP_002504566.1 hypothetical protein -
KFV42_RS04130 (KFV42_04130) 819042..819584 + 543 WP_002504565.1 hypothetical protein -
KFV42_RS04135 (KFV42_04135) 819577..819753 + 177 WP_002504564.1 hypothetical protein -
KFV42_RS04140 (KFV42_04140) 819773..819994 + 222 WP_002504563.1 hypothetical protein -
KFV42_RS04145 (KFV42_04145) 819994..820719 + 726 WP_010959229.1 metallophosphoesterase -
KFV42_RS04150 (KFV42_04150) 820712..821029 + 318 WP_002504561.1 hypothetical protein -
KFV42_RS04155 (KFV42_04155) 821029..821679 + 651 WP_002504560.1 hypothetical protein -
KFV42_RS04160 (KFV42_04160) 821679..822197 + 519 WP_002504559.1 metallophosphoesterase -
KFV42_RS04165 (KFV42_04165) 822360..822590 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV42_RS04170 (KFV42_04170) 822590..822985 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV42_RS04175 (KFV42_04175) 823348..823479 + 132 WP_257243913.1 hypothetical protein -
KFV42_RS04180 (KFV42_04180) 823463..823732 + 270 WP_000755772.1 hypothetical protein -
KFV42_RS04185 (KFV42_04185) 823789..824283 + 495 WP_010959224.1 hypothetical protein -
KFV42_RS04190 (KFV42_04190) 824287..825087 + 801 WP_000686449.1 metallophosphoesterase -
KFV42_RS04195 (KFV42_04195) 825196..825918 + 723 WP_002504538.1 hypothetical protein -
KFV42_RS04200 (KFV42_04200) 826024..826665 + 642 WP_002504537.1 hypothetical protein -
KFV42_RS13340 826696..826830 - 135 WP_002504536.1 hypothetical protein -
KFV42_RS04205 (KFV42_04205) 826913..827317 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721613..854557 132944
- inside Prophage aac(6')-aph(2'') - 789976..858436 68460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200369 WP_002504557.1 NZ_CP073836:822590-822985 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200369 NZ_CP097837:c900320-899859 [Shigella flexneri]
TTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACTG
TGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGAC
AACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCGG
AAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCCGGCATTACC
AATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCGA
CACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200369 WP_002504558.1 NZ_CP073836:822360-822590 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200369 NZ_CP097837:c900703-900392 [Shigella flexneri]
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References