Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822197..822822 Replicon chromosome
Accession NZ_CP073841
Organism Staphylococcus epidermidis strain B1264787

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV40_RS04165 Protein ID WP_002504557.1
Coordinates 822427..822822 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV40_RS04160 Protein ID WP_002504558.1
Coordinates 822197..822427 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV40_RS04095 (KFV40_04095) 817266..817748 + 483 WP_002504570.1 hypothetical protein -
KFV40_RS04100 (KFV40_04100) 817764..817943 + 180 WP_002504569.1 hypothetical protein -
KFV40_RS04105 (KFV40_04105) 817928..818113 + 186 WP_001187008.1 hypothetical protein -
KFV40_RS04110 (KFV40_04110) 818129..818413 + 285 WP_002504568.1 hypothetical protein -
KFV40_RS04115 (KFV40_04115) 818410..818565 + 156 WP_002504567.1 transcriptional activator RinB -
KFV40_RS04120 (KFV40_04120) 818591..818863 + 273 WP_002504566.1 hypothetical protein -
KFV40_RS04125 (KFV40_04125) 818879..819421 + 543 WP_002504565.1 hypothetical protein -
KFV40_RS04130 (KFV40_04130) 819414..819590 + 177 WP_002504564.1 hypothetical protein -
KFV40_RS04135 (KFV40_04135) 819610..819831 + 222 WP_002504563.1 hypothetical protein -
KFV40_RS04140 (KFV40_04140) 819831..820556 + 726 WP_010959229.1 metallophosphoesterase -
KFV40_RS04145 (KFV40_04145) 820549..820866 + 318 WP_002504561.1 hypothetical protein -
KFV40_RS04150 (KFV40_04150) 820866..821516 + 651 WP_002504560.1 hypothetical protein -
KFV40_RS04155 (KFV40_04155) 821516..822034 + 519 WP_002504559.1 metallophosphoesterase -
KFV40_RS04160 (KFV40_04160) 822197..822427 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV40_RS04165 (KFV40_04165) 822427..822822 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV40_RS04170 (KFV40_04170) 823185..823316 + 132 WP_257243913.1 hypothetical protein -
KFV40_RS04175 (KFV40_04175) 823300..823569 + 270 WP_000755772.1 hypothetical protein -
KFV40_RS04180 (KFV40_04180) 823626..824120 + 495 WP_010959224.1 hypothetical protein -
KFV40_RS04185 (KFV40_04185) 824124..824924 + 801 WP_000686449.1 metallophosphoesterase -
KFV40_RS04190 (KFV40_04190) 825033..825755 + 723 WP_002504538.1 hypothetical protein -
KFV40_RS04195 (KFV40_04195) 825861..826502 + 642 WP_002504537.1 hypothetical protein -
KFV40_RS13400 826533..826667 - 135 WP_002504536.1 hypothetical protein -
KFV40_RS04200 (KFV40_04200) 826750..827154 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721450..855500 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200379 WP_002504557.1 NZ_CP073841:822427-822822 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200379 NZ_CP097837:c4058390-4058115 [Shigella flexneri]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGAAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200379 WP_002504558.1 NZ_CP073841:822197-822427 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200379 NZ_CP097837:c4058118-4057759 [Shigella flexneri]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References