200442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1890446..1891071 Replicon chromosome
Accession NZ_CP073876
Organism Staphylococcus epidermidis strain B1285135

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV37_RS09095 Protein ID WP_002504557.1
Coordinates 1890446..1890841 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV37_RS09100 Protein ID WP_002504558.1
Coordinates 1890841..1891071 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV37_RS09060 (KFV37_09100) 1886114..1886518 + 405 WP_002504535.1 YolD-like family protein -
KFV37_RS13375 1886601..1886735 + 135 WP_002504536.1 hypothetical protein -
KFV37_RS09065 (KFV37_09105) 1886766..1887407 - 642 WP_002504537.1 hypothetical protein -
KFV37_RS09070 (KFV37_09110) 1887513..1888235 - 723 WP_002504538.1 hypothetical protein -
KFV37_RS09075 (KFV37_09115) 1888344..1889144 - 801 WP_000686449.1 metallophosphoesterase -
KFV37_RS09080 (KFV37_09120) 1889148..1889642 - 495 WP_010959224.1 hypothetical protein -
KFV37_RS09085 (KFV37_09125) 1889699..1889968 - 270 WP_000755772.1 hypothetical protein -
KFV37_RS09090 (KFV37_09130) 1889952..1890083 - 132 WP_257243913.1 hypothetical protein -
KFV37_RS09095 (KFV37_09135) 1890446..1890841 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV37_RS09100 (KFV37_09140) 1890841..1891071 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV37_RS09105 (KFV37_09145) 1891234..1891752 - 519 WP_002504559.1 metallophosphoesterase -
KFV37_RS09110 (KFV37_09150) 1891752..1892402 - 651 WP_002504560.1 hypothetical protein -
KFV37_RS09115 (KFV37_09155) 1892402..1892719 - 318 WP_002504561.1 hypothetical protein -
KFV37_RS09120 (KFV37_09160) 1892712..1893437 - 726 WP_010959229.1 metallophosphoesterase -
KFV37_RS09125 (KFV37_09165) 1893437..1893658 - 222 WP_002504563.1 hypothetical protein -
KFV37_RS09130 (KFV37_09170) 1893678..1893854 - 177 WP_002504564.1 hypothetical protein -
KFV37_RS09135 (KFV37_09175) 1893847..1894389 - 543 WP_002504565.1 hypothetical protein -
KFV37_RS09140 (KFV37_09180) 1894405..1894677 - 273 WP_002504566.1 hypothetical protein -
KFV37_RS09145 (KFV37_09185) 1894703..1894858 - 156 WP_002504567.1 transcriptional activator RinB -
KFV37_RS09150 (KFV37_09190) 1894855..1895139 - 285 WP_002504568.1 hypothetical protein -
KFV37_RS09155 (KFV37_09195) 1895155..1895340 - 186 WP_001187008.1 hypothetical protein -
KFV37_RS09160 (KFV37_09200) 1895325..1895504 - 180 WP_002504569.1 hypothetical protein -
KFV37_RS09165 (KFV37_09205) 1895520..1896002 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1856084..1991818 135734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200442 WP_002504557.1 NZ_CP073876:c1890841-1890446 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200442 NZ_CP097881:c1106276-1105947 [Escherichia coli str. K-12 substr. MG1655]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200442 WP_002504558.1 NZ_CP073876:c1891071-1890841 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200442 NZ_CP097881:c1106614-1106297 [Escherichia coli str. K-12 substr. MG1655]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References