200494

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822242..822867 Replicon chromosome
Accession NZ_CP073904
Organism Staphylococcus epidermidis strain V1950266

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV55_RS04245 Protein ID WP_002504557.1
Coordinates 822472..822867 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV55_RS04240 Protein ID WP_002504558.1
Coordinates 822242..822472 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV55_RS04175 (KFV55_04175) 817311..817793 + 483 WP_002504570.1 hypothetical protein -
KFV55_RS04180 (KFV55_04180) 817809..817988 + 180 WP_002504569.1 hypothetical protein -
KFV55_RS04185 (KFV55_04185) 817973..818158 + 186 WP_001187008.1 hypothetical protein -
KFV55_RS04190 (KFV55_04190) 818174..818458 + 285 WP_002504568.1 hypothetical protein -
KFV55_RS04195 (KFV55_04195) 818455..818610 + 156 WP_002504567.1 transcriptional activator RinB -
KFV55_RS04200 (KFV55_04200) 818636..818908 + 273 WP_002504566.1 hypothetical protein -
KFV55_RS04205 (KFV55_04205) 818924..819466 + 543 WP_002504565.1 hypothetical protein -
KFV55_RS04210 (KFV55_04210) 819459..819635 + 177 WP_002504564.1 hypothetical protein -
KFV55_RS04215 (KFV55_04215) 819655..819876 + 222 WP_002504563.1 hypothetical protein -
KFV55_RS04220 (KFV55_04220) 819876..820601 + 726 WP_010959229.1 metallophosphoesterase -
KFV55_RS04225 (KFV55_04225) 820594..820911 + 318 WP_002504561.1 hypothetical protein -
KFV55_RS04230 (KFV55_04230) 820911..821561 + 651 WP_002504560.1 hypothetical protein -
KFV55_RS04235 (KFV55_04235) 821561..822079 + 519 WP_002504559.1 metallophosphoesterase -
KFV55_RS04240 (KFV55_04240) 822242..822472 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV55_RS04245 (KFV55_04245) 822472..822867 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV55_RS04250 (KFV55_04250) 823230..823361 + 132 WP_257243913.1 hypothetical protein -
KFV55_RS04255 (KFV55_04255) 823345..823614 + 270 WP_000755772.1 hypothetical protein -
KFV55_RS04260 (KFV55_04260) 823671..824165 + 495 WP_010959224.1 hypothetical protein -
KFV55_RS04265 (KFV55_04265) 824169..824969 + 801 WP_000686449.1 metallophosphoesterase -
KFV55_RS04270 (KFV55_04270) 825078..825800 + 723 WP_002504538.1 hypothetical protein -
KFV55_RS04275 (KFV55_04275) 825906..826547 + 642 WP_002504537.1 hypothetical protein -
KFV55_RS13500 826578..826712 - 135 WP_002504536.1 hypothetical protein -
KFV55_RS04280 (KFV55_04280) 826795..827199 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721495..855545 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200494 WP_002504557.1 NZ_CP073904:822472-822867 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200494 NZ_CP097883:c1107477-1107148 [Escherichia coli str. K-12 substr. MG1655]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200494 WP_002504558.1 NZ_CP073904:822242-822472 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200494 NZ_CP097883:c1107815-1107498 [Escherichia coli str. K-12 substr. MG1655]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References