Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822159..822784 Replicon chromosome
Accession NZ_CP073881
Organism Staphylococcus epidermidis strain B1286247

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV53_RS04215 Protein ID WP_002504557.1
Coordinates 822389..822784 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV53_RS04210 Protein ID WP_002504558.1
Coordinates 822159..822389 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV53_RS04145 (KFV53_04145) 817228..817710 + 483 WP_002504570.1 hypothetical protein -
KFV53_RS04150 (KFV53_04150) 817726..817905 + 180 WP_002504569.1 hypothetical protein -
KFV53_RS04155 (KFV53_04155) 817890..818075 + 186 WP_001187008.1 hypothetical protein -
KFV53_RS04160 (KFV53_04160) 818091..818375 + 285 WP_002504568.1 hypothetical protein -
KFV53_RS04165 (KFV53_04165) 818372..818527 + 156 WP_002504567.1 transcriptional activator RinB -
KFV53_RS04170 (KFV53_04170) 818553..818825 + 273 WP_002504566.1 hypothetical protein -
KFV53_RS04175 (KFV53_04175) 818841..819383 + 543 WP_002504565.1 hypothetical protein -
KFV53_RS04180 (KFV53_04180) 819376..819552 + 177 WP_002504564.1 hypothetical protein -
KFV53_RS04185 (KFV53_04185) 819572..819793 + 222 WP_002504563.1 hypothetical protein -
KFV53_RS04190 (KFV53_04190) 819793..820518 + 726 WP_010959229.1 metallophosphoesterase -
KFV53_RS04195 (KFV53_04195) 820511..820828 + 318 WP_002504561.1 hypothetical protein -
KFV53_RS04200 (KFV53_04200) 820828..821478 + 651 WP_002504560.1 hypothetical protein -
KFV53_RS04205 (KFV53_04205) 821478..821996 + 519 WP_002504559.1 metallophosphoesterase -
KFV53_RS04210 (KFV53_04210) 822159..822389 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV53_RS04215 (KFV53_04215) 822389..822784 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV53_RS04220 (KFV53_04220) 823087..823278 + 192 WP_002504556.1 hypothetical protein -
KFV53_RS04225 (KFV53_04225) 823262..823531 + 270 WP_000755772.1 hypothetical protein -
KFV53_RS04230 (KFV53_04230) 823588..824082 + 495 WP_010959224.1 hypothetical protein -
KFV53_RS04235 (KFV53_04235) 824086..824886 + 801 WP_000686449.1 metallophosphoesterase -
KFV53_RS04240 (KFV53_04240) 824995..825717 + 723 WP_002504538.1 hypothetical protein -
KFV53_RS04245 (KFV53_04245) 825823..826464 + 642 WP_002504537.1 hypothetical protein -
KFV53_RS13365 826495..826629 - 135 WP_002504536.1 hypothetical protein -
KFV53_RS04250 (KFV53_04250) 826712..827116 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 721412..855462 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200454 WP_002504557.1 NZ_CP073881:822389-822784 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200454 NZ_CP097881:3363163-3363381 [Escherichia coli str. K-12 substr. MG1655]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200454 WP_002504558.1 NZ_CP073881:822159-822389 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200454 NZ_CP097881:3362763-3363137 [Escherichia coli str. K-12 substr. MG1655]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References