Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1804320..1804945 Replicon chromosome
Accession NZ_CP093179
Organism Staphylococcus epidermidis strain TMDU-190

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag MNU31_RS08930 Protein ID WP_002504557.1
Coordinates 1804320..1804715 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag MNU31_RS08935 Protein ID WP_002504558.1
Coordinates 1804715..1804945 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU31_RS08895 (MNU31_08900) 1799988..1800392 + 405 WP_002504535.1 YolD-like family protein -
MNU31_RS08900 (MNU31_08905) 1800640..1801281 - 642 WP_002504537.1 hypothetical protein -
MNU31_RS08905 (MNU31_08910) 1801387..1802109 - 723 WP_002504538.1 hypothetical protein -
MNU31_RS08910 (MNU31_08915) 1802218..1803018 - 801 WP_000686449.1 metallophosphoesterase -
MNU31_RS08915 (MNU31_08920) 1803022..1803516 - 495 WP_010959224.1 hypothetical protein -
MNU31_RS08920 (MNU31_08925) 1803573..1803842 - 270 WP_000755772.1 hypothetical protein -
MNU31_RS08925 (MNU31_08930) 1803826..1804017 - 192 WP_002504556.1 hypothetical protein -
MNU31_RS08930 (MNU31_08935) 1804320..1804715 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MNU31_RS08935 (MNU31_08940) 1804715..1804945 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
MNU31_RS08940 (MNU31_08945) 1805108..1805626 - 519 WP_002504559.1 metallophosphoesterase -
MNU31_RS08945 (MNU31_08950) 1805626..1806276 - 651 WP_002504560.1 hypothetical protein -
MNU31_RS08950 (MNU31_08955) 1806276..1806593 - 318 WP_002504561.1 hypothetical protein -
MNU31_RS08955 (MNU31_08960) 1806586..1807311 - 726 WP_010959229.1 metallophosphoesterase -
MNU31_RS08960 (MNU31_08965) 1807311..1807532 - 222 WP_002504563.1 hypothetical protein -
MNU31_RS08965 (MNU31_08970) 1807552..1807728 - 177 WP_002504564.1 hypothetical protein -
MNU31_RS08970 (MNU31_08975) 1807721..1808263 - 543 WP_002504565.1 hypothetical protein -
MNU31_RS08975 (MNU31_08980) 1808279..1808551 - 273 WP_002504566.1 hypothetical protein -
MNU31_RS08980 (MNU31_08985) 1808577..1808732 - 156 WP_002504567.1 transcriptional activator RinB -
MNU31_RS08985 (MNU31_08990) 1808729..1809013 - 285 WP_002504568.1 hypothetical protein -
MNU31_RS08990 (MNU31_08995) 1809029..1809214 - 186 WP_001187008.1 hypothetical protein -
MNU31_RS08995 (MNU31_09000) 1809394..1809876 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1772747..1905119 132372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T237754 WP_002504557.1 NZ_CP093179:c1804715-1804320 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T237754 NZ_LR882500:c2873594-2873199 [Mycobacterium tuberculosis variant microti]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT237754 WP_002504558.1 NZ_CP093179:c1804945-1804715 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT237754 NZ_LR882500:c2873836-2873591 [Mycobacterium tuberculosis variant microti]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References