Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1890651..1891276 Replicon chromosome
Accession NZ_CP073855
Organism Staphylococcus epidermidis strain B1269488

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV48_RS09095 Protein ID WP_002504557.1
Coordinates 1890651..1891046 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV48_RS09100 Protein ID WP_002504558.1
Coordinates 1891046..1891276 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV48_RS09060 (KFV48_09080) 1886319..1886723 + 405 WP_002504535.1 YolD-like family protein -
KFV48_RS13560 1886806..1886940 + 135 WP_002504536.1 hypothetical protein -
KFV48_RS09065 (KFV48_09085) 1886971..1887612 - 642 WP_002504537.1 hypothetical protein -
KFV48_RS09070 (KFV48_09090) 1887718..1888440 - 723 WP_002504538.1 hypothetical protein -
KFV48_RS09075 (KFV48_09095) 1888549..1889349 - 801 WP_000686449.1 metallophosphoesterase -
KFV48_RS09080 (KFV48_09100) 1889353..1889847 - 495 WP_010959224.1 hypothetical protein -
KFV48_RS09085 (KFV48_09105) 1889904..1890173 - 270 WP_000755772.1 hypothetical protein -
KFV48_RS09090 (KFV48_09110) 1890157..1890288 - 132 WP_257243913.1 hypothetical protein -
KFV48_RS09095 (KFV48_09115) 1890651..1891046 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV48_RS09100 (KFV48_09120) 1891046..1891276 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV48_RS09105 (KFV48_09125) 1891439..1891957 - 519 WP_002504559.1 metallophosphoesterase -
KFV48_RS09110 (KFV48_09130) 1891957..1892607 - 651 WP_002504560.1 hypothetical protein -
KFV48_RS09115 (KFV48_09135) 1892607..1892924 - 318 WP_002504561.1 hypothetical protein -
KFV48_RS09120 (KFV48_09140) 1892917..1893642 - 726 WP_010959229.1 metallophosphoesterase -
KFV48_RS09125 (KFV48_09145) 1893642..1893863 - 222 WP_002504563.1 hypothetical protein -
KFV48_RS09130 (KFV48_09150) 1893883..1894059 - 177 WP_002504564.1 hypothetical protein -
KFV48_RS09135 (KFV48_09155) 1894052..1894594 - 543 WP_002504565.1 hypothetical protein -
KFV48_RS09140 (KFV48_09160) 1894610..1894882 - 273 WP_002504566.1 hypothetical protein -
KFV48_RS09145 (KFV48_09165) 1894908..1895063 - 156 WP_002504567.1 transcriptional activator RinB -
KFV48_RS09150 (KFV48_09170) 1895060..1895344 - 285 WP_002504568.1 hypothetical protein -
KFV48_RS09155 (KFV48_09175) 1895360..1895545 - 186 WP_001187008.1 hypothetical protein -
KFV48_RS09160 (KFV48_09180) 1895530..1895709 - 180 WP_002504569.1 hypothetical protein -
KFV48_RS09165 (KFV48_09185) 1895725..1896207 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1857973..1992023 134050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200402 WP_002504557.1 NZ_CP073855:c1891046-1890651 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200402 NZ_CP097840:4475416-4475814 [Shigella flexneri]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200402 WP_002504558.1 NZ_CP073855:c1891276-1891046 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200402 NZ_CP097840:4475120-4475413 [Shigella flexneri]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
AGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTTCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
AAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References