200362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1930207..1930832 Replicon chromosome
Accession NZ_CP073835
Organism Staphylococcus epidermidis strain B1230143

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV52_RS09520 Protein ID WP_002504557.1
Coordinates 1930207..1930602 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV52_RS09525 Protein ID WP_002504558.1
Coordinates 1930602..1930832 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV52_RS09485 (KFV52_09495) 1925875..1926279 + 405 WP_002504535.1 YolD-like family protein -
KFV52_RS13820 1926362..1926496 + 135 WP_002504536.1 hypothetical protein -
KFV52_RS09490 (KFV52_09500) 1926527..1927168 - 642 WP_002504537.1 hypothetical protein -
KFV52_RS09495 (KFV52_09505) 1927274..1927996 - 723 WP_002504538.1 hypothetical protein -
KFV52_RS09500 (KFV52_09510) 1928105..1928905 - 801 WP_000686449.1 metallophosphoesterase -
KFV52_RS09505 (KFV52_09515) 1928909..1929403 - 495 WP_010959224.1 hypothetical protein -
KFV52_RS09510 (KFV52_09520) 1929460..1929729 - 270 WP_000755772.1 hypothetical protein -
KFV52_RS09515 (KFV52_09525) 1929713..1929844 - 132 WP_257243913.1 hypothetical protein -
KFV52_RS09520 (KFV52_09530) 1930207..1930602 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV52_RS09525 (KFV52_09535) 1930602..1930832 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV52_RS09530 (KFV52_09540) 1930995..1931513 - 519 WP_002504559.1 metallophosphoesterase -
KFV52_RS09535 (KFV52_09545) 1931513..1932163 - 651 WP_002504560.1 hypothetical protein -
KFV52_RS09540 (KFV52_09550) 1932163..1932480 - 318 WP_002504561.1 hypothetical protein -
KFV52_RS09545 (KFV52_09555) 1932473..1933198 - 726 WP_010959229.1 metallophosphoesterase -
KFV52_RS09550 (KFV52_09560) 1933198..1933419 - 222 WP_002504563.1 hypothetical protein -
KFV52_RS09555 (KFV52_09565) 1933439..1933615 - 177 WP_002504564.1 hypothetical protein -
KFV52_RS09560 (KFV52_09570) 1933608..1934150 - 543 WP_002504565.1 hypothetical protein -
KFV52_RS09565 (KFV52_09575) 1934166..1934438 - 273 WP_002504566.1 hypothetical protein -
KFV52_RS09570 (KFV52_09580) 1934464..1934619 - 156 WP_002504567.1 transcriptional activator RinB -
KFV52_RS09575 (KFV52_09585) 1934616..1934900 - 285 WP_002504568.1 hypothetical protein -
KFV52_RS09580 (KFV52_09590) 1934916..1935101 - 186 WP_001187008.1 hypothetical protein -
KFV52_RS09585 (KFV52_09595) 1935086..1935265 - 180 WP_002504569.1 hypothetical protein -
KFV52_RS09590 (KFV52_09600) 1935281..1935763 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1895845..2031578 135733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200362 WP_002504557.1 NZ_CP073835:c1930602-1930207 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200362 NZ_CP097834:4270626-4271033 [Shigella flexneri]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200362 WP_002504558.1 NZ_CP073835:c1930832-1930602 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200362 NZ_CP097834:4270379-4270645 [Shigella flexneri]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References