200394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 822252..822877 Replicon chromosome
Accession NZ_CP073850
Organism Staphylococcus epidermidis strain B1266911

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV33_RS04245 Protein ID WP_002504557.1
Coordinates 822482..822877 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV33_RS04240 Protein ID WP_002504558.1
Coordinates 822252..822482 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV33_RS04175 (KFV33_04175) 817321..817803 + 483 WP_002504570.1 hypothetical protein -
KFV33_RS04180 (KFV33_04180) 817819..817998 + 180 WP_002504569.1 hypothetical protein -
KFV33_RS04185 (KFV33_04185) 817983..818168 + 186 WP_001187008.1 hypothetical protein -
KFV33_RS04190 (KFV33_04190) 818184..818468 + 285 WP_002504568.1 hypothetical protein -
KFV33_RS04195 (KFV33_04195) 818465..818620 + 156 WP_002504567.1 transcriptional activator RinB -
KFV33_RS04200 (KFV33_04200) 818646..818918 + 273 WP_002504566.1 hypothetical protein -
KFV33_RS04205 (KFV33_04205) 818934..819476 + 543 WP_002504565.1 hypothetical protein -
KFV33_RS04210 (KFV33_04210) 819469..819645 + 177 WP_002504564.1 hypothetical protein -
KFV33_RS04215 (KFV33_04215) 819665..819886 + 222 WP_002504563.1 hypothetical protein -
KFV33_RS04220 (KFV33_04220) 819886..820611 + 726 WP_010959229.1 metallophosphoesterase -
KFV33_RS04225 (KFV33_04225) 820604..820921 + 318 WP_002504561.1 hypothetical protein -
KFV33_RS04230 (KFV33_04230) 820921..821571 + 651 WP_002504560.1 hypothetical protein -
KFV33_RS04235 (KFV33_04235) 821571..822089 + 519 WP_002504559.1 metallophosphoesterase -
KFV33_RS04240 (KFV33_04240) 822252..822482 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV33_RS04245 (KFV33_04245) 822482..822877 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV33_RS04250 (KFV33_04250) 823240..823371 + 132 WP_257243913.1 hypothetical protein -
KFV33_RS04255 (KFV33_04255) 823355..823624 + 270 WP_000755772.1 hypothetical protein -
KFV33_RS04260 (KFV33_04260) 823681..824175 + 495 WP_010959224.1 hypothetical protein -
KFV33_RS04265 (KFV33_04265) 824179..824979 + 801 WP_000686449.1 metallophosphoesterase -
KFV33_RS04270 (KFV33_04270) 825088..825810 + 723 WP_002504538.1 hypothetical protein -
KFV33_RS04275 (KFV33_04275) 825916..826557 + 642 WP_002504537.1 hypothetical protein -
KFV33_RS13340 826588..826722 - 135 WP_002504536.1 hypothetical protein -
KFV33_RS04280 (KFV33_04280) 826805..827209 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') / fusB groEL 721505..888169 166664


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200394 WP_002504557.1 NZ_CP073850:822482-822877 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200394 NZ_CP097840:2728499-2728654 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200394 WP_002504558.1 NZ_CP073850:822252-822482 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200394 NZ_CP097840:c2728487-2728429 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References