Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1893054..1893679 Replicon chromosome
Accession NZ_CP073863
Organism Staphylococcus epidermidis strain B1276296

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV46_RS09020 Protein ID WP_002504557.1
Coordinates 1893054..1893449 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV46_RS09025 Protein ID WP_002504558.1
Coordinates 1893449..1893679 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV46_RS08985 (KFV46_08995) 1888722..1889126 + 405 WP_002504535.1 YolD-like family protein -
KFV46_RS13360 1889209..1889343 + 135 WP_002504536.1 hypothetical protein -
KFV46_RS08990 (KFV46_09000) 1889374..1890015 - 642 WP_002504537.1 hypothetical protein -
KFV46_RS08995 (KFV46_09005) 1890121..1890843 - 723 WP_002504538.1 hypothetical protein -
KFV46_RS09000 (KFV46_09010) 1890952..1891752 - 801 WP_000686449.1 metallophosphoesterase -
KFV46_RS09005 (KFV46_09015) 1891756..1892250 - 495 WP_010959224.1 hypothetical protein -
KFV46_RS09010 (KFV46_09020) 1892307..1892576 - 270 WP_000755772.1 hypothetical protein -
KFV46_RS09015 (KFV46_09025) 1892560..1892691 - 132 WP_257243913.1 hypothetical protein -
KFV46_RS09020 (KFV46_09030) 1893054..1893449 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV46_RS09025 (KFV46_09035) 1893449..1893679 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV46_RS09030 (KFV46_09040) 1893842..1894360 - 519 WP_002504559.1 metallophosphoesterase -
KFV46_RS09035 (KFV46_09045) 1894360..1895010 - 651 WP_002504560.1 hypothetical protein -
KFV46_RS09040 (KFV46_09050) 1895010..1895327 - 318 WP_002504561.1 hypothetical protein -
KFV46_RS09045 (KFV46_09055) 1895320..1896045 - 726 WP_010959229.1 metallophosphoesterase -
KFV46_RS09050 (KFV46_09060) 1896045..1896266 - 222 WP_002504563.1 hypothetical protein -
KFV46_RS09055 (KFV46_09065) 1896286..1896462 - 177 WP_002504564.1 hypothetical protein -
KFV46_RS09060 (KFV46_09070) 1896455..1896997 - 543 WP_002504565.1 hypothetical protein -
KFV46_RS09065 (KFV46_09075) 1897013..1897285 - 273 WP_002504566.1 hypothetical protein -
KFV46_RS09070 (KFV46_09080) 1897311..1897466 - 156 WP_002504567.1 transcriptional activator RinB -
KFV46_RS09075 (KFV46_09085) 1897463..1897747 - 285 WP_002504568.1 hypothetical protein -
KFV46_RS09080 (KFV46_09090) 1897763..1897948 - 186 WP_001187008.1 hypothetical protein -
KFV46_RS09085 (KFV46_09095) 1897933..1898112 - 180 WP_002504569.1 hypothetical protein -
KFV46_RS09090 (KFV46_09100) 1898128..1898610 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') - 1861482..1994426 132944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200422 WP_002504557.1 NZ_CP073863:c1893449-1893054 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200422 NZ_CP097858:3032539-3032862 [Vibrio owensii]
ATGAGCTGGAAGATCGACTTTTACGATGGCGTTGAGGAGCAGATCCTCGATATGCCTCCAAAAATACAAGCTCGCATGAT
TAAGCTTTTAGAGCTGATGGAAAAGCATGGTGCAAACTTGGGGCCTCCTCATACTGAGTCTATGGGCGATGGGTTATTTG
AAATCCGCGCCAAAGCTCAAGAAGGTATTGGTAGAGGCTTATTTTGCTACTTAAAAGGGAAGCACATTTATGTGTTACAC
GCTTTTGTAAAAAAATCTCAAAAGACGCCCAAAAATGAGCTTAATCTTGCCAGAGATAGACAAAAAGAGGTTCAAAAATC
ATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200422 WP_002504558.1 NZ_CP073863:c1893679-1893449 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200422 NZ_CP097858:3032859-3033137 [Vibrio owensii]
ATGAGTCTGCAAAAACTGAAACAACGTGCTTTAGCCAATGCTGATGTTAAGAATGAGTACGATAAGCTTGAGAGTGAGTT
CAGCTTTATTGACCAATTGCTTACCATGAGAACAAAGGCAGGACTTACTCAAGAACAAGTTGCTGAAAGAATGCATACCC
AAAAAAGTAATGTCAGTCGTTTAGAAAAAGGTAATGCCAATCCAAGTTGGTCAACTCTTCTAAAATATGCTCACGCATGT
GGCTTTGAACTAACACTCAAGCCACAAAAAATGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References