Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4972956..4973542 Replicon chromosome
Accession NC_016845
Organism Klebsiella pneumoniae subsp. pneumoniae HS11286

Toxin (Protein)


Gene name doc Uniprot ID A0A0H3GUD1
Locus tag KPHS_49670 Protein ID YP_005229267.1
Coordinates 4972956..4973324 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag KPHS_49680 Protein ID YP_005229268.1
Coordinates 4973321..4973542 (-) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPHS_49630 4968459..4969529 - 1071 YP_005229263.1 glycerol-3-phosphate transporter ATP-binding subunit -
KPHS_49640 4969531..4970376 - 846 YP_005229264.1 sn-glycerol 3-phosphate transport membrane component -
KPHS_49650 4970373..4971260 - 888 YP_005229265.1 glycerol-3-phosphate transporter permease -
KPHS_49660 4971367..4972683 - 1317 YP_005229266.1 glycerol-3-phosphate transporter periplasmic binding protein -
KPHS_49670 4972956..4973324 - 369 YP_005229267.1 death -on-curing protein of phage P1 Toxin
KPHS_49680 4973321..4973542 - 222 YP_005229268.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KPHS_49690 4973706..4974419 - 714 YP_005229269.1 branched-chain amino acid transport system ATP-binding protein -
KPHS_49700 4974421..4975188 - 768 YP_005229270.1 leucine/isoleucine/valine transporter ATP-binding subunit -
KPHS_49710 4975185..4976462 - 1278 YP_005229271.1 leucine/isoleucine/valine transporter permease subunit -
KPHS_49720 4976459..4977385 - 927 YP_005229272.1 high-affinity branched-chain amino acid transporter membrane component -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4967722..4988310 20588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-49)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T26031 YP_005229267.1 NC_016845:c4973324-4972956 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T26031 NC_016845:c4973324-4972956 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT26031 YP_005229268.1 NC_016845:c4973542-4973321 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT26031 NC_016845:c4973542-4973321 [Klebsiella pneumoniae subsp. pneumoniae HS11286]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References