Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3435720..3436306 Replicon chromosome
Accession NZ_CP064129
Organism Klebsiella pneumoniae strain M911-1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag IOD52_RS16995 Protein ID WP_002920800.1
Coordinates 3435720..3436088 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag IOD52_RS17000 Protein ID WP_004174006.1
Coordinates 3436085..3436306 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD52_RS16975 3431223..3432293 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
IOD52_RS16980 3432295..3433140 - 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
IOD52_RS16985 3433137..3434024 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
IOD52_RS16990 3434131..3435447 - 1317 WP_032442539.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
IOD52_RS16995 3435720..3436088 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IOD52_RS17000 3436085..3436306 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IOD52_RS17005 3436470..3437183 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
IOD52_RS17010 3437185..3437952 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
IOD52_RS17015 3437949..3439226 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
IOD52_RS17020 3439223..3440149 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3430486..3451196 20710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T180361 WP_002920800.1 NZ_CP064129:c3436088-3435720 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T180361 NZ_CP085190:c53443-53309 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT180361 WP_004174006.1 NZ_CP064129:c3436306-3436085 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT180361 NZ_CP085190:53488-53548 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References