Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 438953..439539 Replicon chromosome
Accession NZ_CP084823
Organism Klebsiella pneumoniae strain T69

Toxin (Protein)


Gene name doc Uniprot ID A0A7Z9B6M3
Locus tag LGM19_RS02255 Protein ID WP_029884514.1
Coordinates 438953..439321 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LGM19_RS02260 Protein ID WP_004174006.1
Coordinates 439318..439539 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM19_RS02235 (434456) 434456..435526 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
LGM19_RS02240 (435528) 435528..436373 - 846 WP_004901101.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LGM19_RS02245 (436370) 436370..437257 - 888 WP_004901104.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LGM19_RS02250 (437364) 437364..438680 - 1317 WP_004901106.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LGM19_RS02255 (438953) 438953..439321 - 369 WP_029884514.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LGM19_RS02260 (439318) 439318..439539 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LGM19_RS02265 (439703) 439703..440416 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LGM19_RS02270 (440418) 440418..441185 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LGM19_RS02275 (441182) 441182..442459 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
LGM19_RS02280 (442456) 442456..443382 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 433719..454680 20961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13583.01 Da        Isoelectric Point: 8.6410

>T219456 WP_029884514.1 NZ_CP084823:c439321-438953 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRMALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T219456 NZ_CP116458:407945-408229 [Acidithiobacillus ferriphilus]
ATGAAGCTGTTCTGGACGCCGGAGGCGATCCAAGACCGCGACAACATCTATGACCATATCGAGGCCGACAACCCGGCTGC
CGCGTTGGCTCTCGATAATCTGTTTTCAAAGAAGGCGGATCGCTTGGTAGATCACCCCGGTCAGGGACGGCCTGGGCGCA
TTGTCGGTACCCGCGAACTGGTAGCACATAGGAATTACATCCTGGTCTATGACTTGGCAAAAGACCTGGTTCGCGTGCTG
CGCGTCCTGCACGCGGCTCGGCAGTGGCCGCCAGTGAAGATGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT219456 WP_004174006.1 NZ_CP084823:c439539-439318 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT219456 NZ_CP116458:407658-407945 [Acidithiobacillus ferriphilus]
ATGAGCGAAGCTACCTTTACTTTTCGGGTCGATGAAGCCTTGAAAACCGAGTTCTCAACGGCCGCCAAGGCGCGCGACCG
CAGCGGCGCGCAACTCCTGCGTGACTTCATGCGCGAGTTCGTGCAGCAGCAACAGGAAGCGGCCGCGCATGACACATGGT
TCCGTCGCCAGGTGCAAATGGGTCTGGACTCCGCCAATGCCGGCAACCTCGTTCCAGCGGCCGAGGTGGAAGCCAGGTTT
GCGGCCAGGCGGATGGCCACGCGTCGCCGACTTGAAGCCTCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9B6M3

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References