Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 438953..439539 | Replicon | chromosome |
Accession | NZ_CP084823 | ||
Organism | Klebsiella pneumoniae strain T69 |
Toxin (Protein)
Gene name | doc | Uniprot ID | A0A7Z9B6M3 |
Locus tag | LGM19_RS02255 | Protein ID | WP_029884514.1 |
Coordinates | 438953..439321 (-) | Length | 123 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | W9B1V1 |
Locus tag | LGM19_RS02260 | Protein ID | WP_004174006.1 |
Coordinates | 439318..439539 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LGM19_RS02235 (434456) | 434456..435526 | - | 1071 | WP_004150074.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
LGM19_RS02240 (435528) | 435528..436373 | - | 846 | WP_004901101.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
LGM19_RS02245 (436370) | 436370..437257 | - | 888 | WP_004901104.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
LGM19_RS02250 (437364) | 437364..438680 | - | 1317 | WP_004901106.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
LGM19_RS02255 (438953) | 438953..439321 | - | 369 | WP_029884514.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
LGM19_RS02260 (439318) | 439318..439539 | - | 222 | WP_004174006.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
LGM19_RS02265 (439703) | 439703..440416 | - | 714 | WP_004145133.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
LGM19_RS02270 (440418) | 440418..441185 | - | 768 | WP_002920803.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
LGM19_RS02275 (441182) | 441182..442459 | - | 1278 | WP_004174005.1 | branched chain amino acid ABC transporter permease LivM | - |
LGM19_RS02280 (442456) | 442456..443382 | - | 927 | WP_002920807.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 433719..454680 | 20961 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13583.01 Da Isoelectric Point: 8.6410
>T219456 WP_029884514.1 NZ_CP084823:c439321-438953 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRMALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRMALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
Download Length: 369 bp
>T219456 NZ_CP116458:407945-408229 [Acidithiobacillus ferriphilus]
ATGAAGCTGTTCTGGACGCCGGAGGCGATCCAAGACCGCGACAACATCTATGACCATATCGAGGCCGACAACCCGGCTGC
CGCGTTGGCTCTCGATAATCTGTTTTCAAAGAAGGCGGATCGCTTGGTAGATCACCCCGGTCAGGGACGGCCTGGGCGCA
TTGTCGGTACCCGCGAACTGGTAGCACATAGGAATTACATCCTGGTCTATGACTTGGCAAAAGACCTGGTTCGCGTGCTG
CGCGTCCTGCACGCGGCTCGGCAGTGGCCGCCAGTGAAGATGTGA
ATGAAGCTGTTCTGGACGCCGGAGGCGATCCAAGACCGCGACAACATCTATGACCATATCGAGGCCGACAACCCGGCTGC
CGCGTTGGCTCTCGATAATCTGTTTTCAAAGAAGGCGGATCGCTTGGTAGATCACCCCGGTCAGGGACGGCCTGGGCGCA
TTGTCGGTACCCGCGAACTGGTAGCACATAGGAATTACATCCTGGTCTATGACTTGGCAAAAGACCTGGTTCGCGTGCTG
CGCGTCCTGCACGCGGCTCGGCAGTGGCCGCCAGTGAAGATGTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8151.15 Da Isoelectric Point: 4.7769
>AT219456 WP_004174006.1 NZ_CP084823:c439539-439318 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT219456 NZ_CP116458:407658-407945 [Acidithiobacillus ferriphilus]
ATGAGCGAAGCTACCTTTACTTTTCGGGTCGATGAAGCCTTGAAAACCGAGTTCTCAACGGCCGCCAAGGCGCGCGACCG
CAGCGGCGCGCAACTCCTGCGTGACTTCATGCGCGAGTTCGTGCAGCAGCAACAGGAAGCGGCCGCGCATGACACATGGT
TCCGTCGCCAGGTGCAAATGGGTCTGGACTCCGCCAATGCCGGCAACCTCGTTCCAGCGGCCGAGGTGGAAGCCAGGTTT
GCGGCCAGGCGGATGGCCACGCGTCGCCGACTTGAAGCCTCTGAGTGA
ATGAGCGAAGCTACCTTTACTTTTCGGGTCGATGAAGCCTTGAAAACCGAGTTCTCAACGGCCGCCAAGGCGCGCGACCG
CAGCGGCGCGCAACTCCTGCGTGACTTCATGCGCGAGTTCGTGCAGCAGCAACAGGAAGCGGCCGCGCATGACACATGGT
TCCGTCGCCAGGTGCAAATGGGTCTGGACTCCGCCAATGCCGGCAACCTCGTTCCAGCGGCCGAGGTGGAAGCCAGGTTT
GCGGCCAGGCGGATGGCCACGCGTCGCCGACTTGAAGCCTCTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7Z9B6M3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E5YJY7 |