188835

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 337051..337637 Replicon chromosome
Accession NZ_CP069046
Organism Klebsiella pneumoniae strain 33Kpn22

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag IFY68_RS01555 Protein ID WP_002920800.1
Coordinates 337269..337637 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag IFY68_RS01550 Protein ID WP_002920802.1
Coordinates 337051..337272 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFY68_RS01530 333208..334134 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
IFY68_RS01535 334131..335408 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
IFY68_RS01540 335405..336172 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
IFY68_RS01545 336174..336887 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
IFY68_RS01550 337051..337272 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IFY68_RS01555 337269..337637 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IFY68_RS01560 337910..339226 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
IFY68_RS01565 339333..340220 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
IFY68_RS01570 340217..341062 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
IFY68_RS01575 341064..342134 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 322283..342871 20588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T188835 WP_002920800.1 NZ_CP069046:337269-337637 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T188835 NZ_CP090580:c314093-313659 [Methylobacterium radiotolerans]
ATGAGTGAGCGGTTCCTGCTCGATACCAATATCATCTCCGAGATCGTGAAGCAGGGCAGGGACAGCGTCGTTCTAGGTGT
GATCGCCCAGGTCGGCGAGGACAGCATCTGCACCAGCGCCATCGTCGCCAGCGAGCTACGCTTCGGCGTCGAGCGGAAGC
GATCCCAGGCCCTGCGGGAGAAAGTCGAGCGCGTGCTGCGCAACATCGAAGTACTACCATATAACTCCGGCTGCTCGCAG
AGCTACGGCATCATCCGTGCGGCGTTGGAGCGTGAGGGCAGGGGGATCGGGCCCAACGATCTGCTGATCGCCGCCCAAGC
GCATTCTCTAGGTATGACCCTGGTGACCGACAACGTCCACGAGTTTGAACGAGTCGCCGGTCTTCGGGTAGTCAATTGGC
TCGATCCGTCATACTCTTTCAGGGCCGCTAAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT188835 WP_002920802.1 NZ_CP069046:337051-337272 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT188835 NZ_CP090580:c314329-314090 [Methylobacterium radiotolerans]
ATGGATGGAAAGACGGCGAGCCTGTTCCGGAATGGCCGCAATCAGGCACTGCGCATTCCCCGAGAGTATGAGCTTCCCGG
CACCAGCGCGCGCATCCGCAGACTGCCGAATGGCAATCTCGAAATCGAGCCTGTGGCCGAGACCGGGCTGCTGGCGGCCT
TCAAGGACGAGCTGCCCCTTCCGCCACAGGATTGCATGGACCCCGTCCTCGAACTTCCTATCGAGGCAGTGGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References