194349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4822773..4823359 Replicon chromosome
Accession NZ_CP070564
Organism Klebsiella pneumoniae strain KP51069

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag JW299_RS25790 Protein ID WP_002920800.1
Coordinates 4822773..4823141 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag JW299_RS25795 Protein ID WP_002920802.1
Coordinates 4823138..4823359 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW299_RS25770 4818276..4819346 - 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
JW299_RS25775 4819348..4820193 - 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
JW299_RS25780 4820190..4821077 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
JW299_RS25785 4821184..4822500 - 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
JW299_RS25790 4822773..4823141 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JW299_RS25795 4823138..4823359 - 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JW299_RS25800 4823523..4824236 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
JW299_RS25805 4824238..4825005 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JW299_RS25810 4825002..4826279 - 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
JW299_RS25815 4826276..4827202 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4817539..4838127 20588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T194349 WP_002920800.1 NZ_CP070564:c4823141-4822773 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T194349 NZ_CP093445:1977295-1977471 [Salmonella enterica subsp. enterica serovar Abeokuta]
GTGAAGCAAGGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGAGTCGAGGTTTCAAACGGCACCAACCATTTGAAACTCAG
ATATAACGGGAAGCGCAGCGTAATGCCAAGACATCCCGGCGATGAGATAAAAGAACCACTAAGAAGGGCCATACTCAAGC
AGTTAGGCCTGAATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT194349 WP_002920802.1 NZ_CP070564:c4823359-4823138 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT194349 NZ_CP093445:1977519-1977935 [Salmonella enterica subsp. enterica serovar Abeokuta]
ATGCGATACCCATTAAATTTAGTACCAGCGCCGGAAGGCGGCTATGTTGTGACATTCCCGGATATCCCCGAGGCATTAAC
GCAGGGGGATACGCGGGAAGAAGCGTTAAGCGCAGCGCTTGATGCACTGGTTACAGCGTTTGAATTCTATTTCGAGGACA
ACGAGCAGATCCCGCTGCCGTCCGAGGTAAATGCTGGTGATGATTTTGTCGAAGTACCGTTAAGCGTGGCGTCGAAAGTG
CTGTTGCTAAACGCTTTCCTTGAGTCGCGCCTTACCCAGCAGGAGCTGGCAAAGCGCATCGGTAAGCCCCGACAGGAAAT
TACGCGACTGTTTGATCTGAATCACGCCACAAAAATTGATGCGGTTCAGTCGGCGGCGAAAGCGTTGGGCAGGGAACTGA
CACTCAATATCATGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References