Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 326066..326652 Replicon chromosome
Accession NZ_CP051490
Organism Klebsiella pneumoniae strain M297-1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HGK25_RS01690 Protein ID WP_002920800.1
Coordinates 326066..326434 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HGK25_RS01695 Protein ID WP_004174006.1
Coordinates 326431..326652 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGK25_RS01670 (HGK25_01705) 321569..322639 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
HGK25_RS01675 (HGK25_01710) 322641..323486 - 846 WP_004174009.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HGK25_RS01680 (HGK25_01715) 323483..324370 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HGK25_RS01685 (HGK25_01720) 324477..325793 - 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HGK25_RS01690 (HGK25_01725) 326066..326434 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HGK25_RS01695 (HGK25_01730) 326431..326652 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HGK25_RS01700 (HGK25_01735) 326816..327529 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HGK25_RS01705 (HGK25_01740) 327531..328298 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HGK25_RS01710 (HGK25_01745) 328295..329572 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HGK25_RS01715 (HGK25_01750) 329569..330495 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 320832..342618 21786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T154308 WP_002920800.1 NZ_CP051490:c326434-326066 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T154308 NZ_CP067994:2615705-2615812 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT154308 WP_004174006.1 NZ_CP051490:c326652-326431 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT154308 NZ_CP067994:c2615658-2615592 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References