Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4873879..4874465 Replicon chromosome
Accession NZ_CP073791
Organism Klebsiella pneumoniae isolate KP_NORM_BLD_2010_71621

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag KFO61_RS23955 Protein ID WP_002920800.1
Coordinates 4873879..4874247 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag KFO61_RS23960 Protein ID WP_002920802.1
Coordinates 4874244..4874465 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFO61_RS23935 (KFO61_23935) 4869382..4870452 - 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
KFO61_RS23940 (KFO61_23940) 4870454..4871299 - 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KFO61_RS23945 (KFO61_23945) 4871296..4872183 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KFO61_RS23950 (KFO61_23950) 4872290..4873606 - 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KFO61_RS23955 (KFO61_23955) 4873879..4874247 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFO61_RS23960 (KFO61_23960) 4874244..4874465 - 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFO61_RS23965 (KFO61_23965) 4874629..4875342 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KFO61_RS23970 (KFO61_23970) 4875344..4876111 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KFO61_RS23975 (KFO61_23975) 4876108..4877385 - 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
KFO61_RS23980 (KFO61_23980) 4877382..4878308 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4868645..4889233 20588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T200304 WP_002920800.1 NZ_CP073791:c4874247-4873879 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T200304 NZ_CP097808:c4731433-4731146 [Klebsiella variicola]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCATTAAGTAATCTACGAAAACATGGAGTCCGGTTTGAAGAAGCGGT
ATTAGTCTTTGACGATCCGCGGCACCTTTCCCGCCAGGAGCGGTTTGAGAATGGTGAATATCGCTGGCAGACCATCGGTC
TTGTGCATGGGATCCTTGTTATCCTGGTGGCGCATTCGGTCCGTTTTGAAAGTGGAACTGAGGTTATTCGTATTATCAGC
GCCCGGAAGGCGGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT200304 WP_002920802.1 NZ_CP073791:c4874465-4874244 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT200304 NZ_CP097808:c4731159-4730857 [Klebsiella variicola]
ATGAGCATGGTTAAACATAAACGCGGCAATACGGCGGCGCTTACCGCTAAGCGTGATGCCGAACTCAAAGCGCTAGCGAG
CAAAGCCGATGAGGATATCGATTACAGCGATATCCCCGCTACAGACGATGCGCAATGGTCAGATGCCGTTCGCGGCAAAT
TTTTTCGACCGCTAAAAACACAGGCTTCTGTGCGCATTGATGCCGATGTCATGGAGTGGCTCAAACGTCCAGGAAAAGGC
TATCAAACTCGACTGAATGCGATTTTAAGAGAAGCGATGATTCGCGATCTTAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References