Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 331562..332148 Replicon chromosome
Accession NZ_CP084860
Organism Klebsiella pneumoniae strain SB1067

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LGM10_RS01545 Protein ID WP_023285605.1
Coordinates 331780..332148 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LGM10_RS01540 Protein ID WP_004174006.1
Coordinates 331562..331783 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM10_RS01520 (327719) 327719..328645 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LGM10_RS01525 (328642) 328642..329919 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
LGM10_RS01530 (329916) 329916..330683 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LGM10_RS01535 (330685) 330685..331398 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LGM10_RS01540 (331562) 331562..331783 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LGM10_RS01545 (331780) 331780..332148 + 369 WP_023285605.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LGM10_RS01550 (332421) 332421..333737 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LGM10_RS01555 (333844) 333844..334731 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LGM10_RS01560 (334728) 334728..335573 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LGM10_RS01565 (335575) 335575..336645 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 315341..337382 22041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13534.89 Da        Isoelectric Point: 8.6410

>T219613 WP_023285605.1 NZ_CP084860:331780-332148 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGITVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T219613 NZ_CP116559:c2579846-2579694 [Enterococcus faecalis]
GTGGTGCGTATGAGCGCACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAAAAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT219613 WP_004174006.1 NZ_CP084860:331562-331783 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT219613 NZ_CP116559:2579575-2579761 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References