Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 5076635..5077221 Replicon chromosome
Accession NZ_CP069821
Organism Klebsiella pneumoniae strain FDAARGOS_1326

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag I6K56_RS24785 Protein ID WP_002920800.1
Coordinates 5076635..5077003 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag I6K56_RS24790 Protein ID WP_004174006.1
Coordinates 5077000..5077221 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K56_RS24765 5072138..5073208 - 1071 WP_032433652.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
I6K56_RS24770 5073210..5074055 - 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
I6K56_RS24775 5074052..5074939 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
I6K56_RS24780 5075046..5076362 - 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
I6K56_RS24785 5076635..5077003 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6K56_RS24790 5077000..5077221 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6K56_RS24795 5077385..5078098 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
I6K56_RS24800 5078100..5078867 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
I6K56_RS24805 5078864..5080141 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
I6K56_RS24810 5080138..5081064 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 5071401..5092360 20959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T191871 WP_002920800.1 NZ_CP069821:c5077003-5076635 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T191871 NZ_CP091977:2154389-2154790 [Aromatoleum aromaticum]
ATGCTGCGCTATCTGCTCGATACGAACATCGTGATCTACGTGATCAAGCGCCGGCCACTGTCGGCATTGGCGCTGTTCAA
CGTGAACGCGGGACATATGGCGATCTCCTCGATCACCCTCGCGGAGCTGATGCACGGCGCCGAGAAAAGCAATGCGCCGG
CGCGTTCGCTTGCCGCCGTGGAGGATTTTTGCAGCCGCCTCGAGGTGCTGCCATACGGTCCGAAAGCCGCAATGCACTAT
GGCAACATCCGTGCTCGACTCGAGTCTCGCGGTCAGACGATCGGTGTCAATGACCTGCACATCGCAGCCCACGCACGCAG
CGAGGGTCTGACGCTCGTGTCGAACAACTTGCGCGAGTTCGAGCGGGTGGAAGCATTGCAACTGGCGAACTGGGCAATCT
GA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT191871 WP_004174006.1 NZ_CP069821:c5077221-5077000 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT191871 NZ_CP091977:2154156-2154389 [Aromatoleum aromaticum]
ATGACCACAACCACCGTCTTCACGAACAATCGCAGCCAGGCCGTGCGACTGCCGGCAGACATGCGCTTGCCCGCGAACGT
CAAGCAAGTGGACATCCGCGCTCGCGGGTTGGAGCGAATCATCGCGCCGGTGGGCCATACGTGGGATTCGTTCTTCATCG
ATGGGCCGCAGGTTGCCGACGATTTCATGGAAACCCGCGCCAGCCAGGAACAGCAGGAACGCGAAGCCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References