Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 327036..327622 Replicon chromosome
Accession NZ_CP086128
Organism Klebsiella pneumoniae strain MIN-109

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag LLZ91_RS01510 Protein ID WP_002920800.1
Coordinates 327254..327622 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LLZ91_RS01505 Protein ID WP_004174006.1
Coordinates 327036..327257 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ91_RS01485 (LLZ91_01485) 323193..324119 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LLZ91_RS01490 (LLZ91_01490) 324116..325393 + 1278 WP_004188292.1 branched chain amino acid ABC transporter permease LivM -
LLZ91_RS01495 (LLZ91_01495) 325390..326157 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LLZ91_RS01500 (LLZ91_01500) 326159..326872 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LLZ91_RS01505 (LLZ91_01505) 327036..327257 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LLZ91_RS01510 (LLZ91_01510) 327254..327622 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LLZ91_RS01515 (LLZ91_01515) 327895..329211 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LLZ91_RS01520 (LLZ91_01520) 329318..330205 + 888 WP_014906831.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LLZ91_RS01525 (LLZ91_01525) 330202..331047 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LLZ91_RS01530 (LLZ91_01530) 331049..332119 + 1071 WP_004188298.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 311899..332856 20957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T222581 WP_002920800.1 NZ_CP086128:327254-327622 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T222581 NZ_CP117966:c3208677-3208387 [Roseburia hominis]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATAAAGCGTGGCTTGAA
GATTGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAACCGCTGCCGGATAAGAACCGCGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT222581 WP_004174006.1 NZ_CP086128:327036-327257 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT222581 NZ_CP117966:c3208952-3208674 [Roseburia hominis]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAGGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References