Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1631815..1632341 Replicon chromosome
Accession NZ_CP037923
Organism Shigella flexneri 5a str. M90T

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EKN05_RS08360 Protein ID WP_000323025.1
Coordinates 1632054..1632341 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EKN05_RS08355 Protein ID WP_000534858.1
Coordinates 1631815..1632054 (+) Length 80 a.a.

Genomic Context

EKN05_RS08330EKN05_RS08345EKN05_RS08355EKN05_RS08360EKN05_RS08365EKN05_RS08370EKN05_RS08375EKN05_RS08380EKN05_RS08385EKN05_RS25085EKN05_RS08410EKN05_RS08415EKN05_RS08335EKN05_RS08340EKN05_RS08350EKN05_RS08420
Location: 1627463..1627666 (204 bp)
Type: Others
Protein ID: WP_000214712.1
Location: 1630332..1631488 (1157 bp)
Type: Others
Protein ID: WP_136350417.1
Location: 1631815..1632054 (240 bp)
Type: Antitoxin
Protein ID: WP_000534858.1
Location: 1632054..1632341 (288 bp)
Type: Toxin
Protein ID: WP_000323025.1
Location: 1632413..1632568 (156 bp)
Type: Others
Protein ID: WP_000813254.1
Location: 1632786..1633037 (252 bp)
Type: Others
Protein ID: WP_000980987.1
Location: 1633104..1633382 (279 bp)
Type: Others
Protein ID: WP_024258459.1
Location: 1633384..1634434 (1051 bp)
Type: Others
Protein ID: Protein_1618
Location: 1634447..1634821 (375 bp)
Type: Others
Protein ID: WP_000904117.1
Location: 1634818..1635639 (822 bp)
Type: Others
Protein ID: Protein_1620
Location: 1636222..1636500 (279 bp)
Type: Others
Protein ID: WP_001017801.1
Location: 1636559..1636667 (109 bp)
Type: Others
Protein ID: Protein_1622
Location: 1627702..1629162 (1461 bp)
Type: Others
Protein ID: WP_000527766.1
Location: 1629251..1630270 (1020 bp)
Type: Others
Protein ID: Protein_1610
Location: 1631485..1631790 (306 bp)
Type: Others
Protein ID: WP_071818640.1
Location: 1636948..1637283 (336 bp)
Type: Others
Protein ID: WP_000871291.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EKN05_RS08330 (EKN05_008360)1627463..1627666+204WP_000214712.1putative selenium delivery protein YdfZ-
EKN05_RS08335 (EKN05_008365)1627702..1629162-1461WP_000527766.1mannitol dehydrogenase family protein-
EKN05_RS08340 (EKN05_008370)1629251..1630270-1020Protein_1610MHS family MFS transporter YdfJ-
EKN05_RS08345 (EKN05_008375)1630332..1631488+1157WP_136350417.1IS3 family transposase-
EKN05_RS08350 (EKN05_008380)1631485..1631790-306WP_071818640.1hypothetical protein-
EKN05_RS08355 (EKN05_008385)1631815..1632054+240WP_000534858.1type II toxin-antitoxin system antitoxin RelBAntitoxin
EKN05_RS08360 (EKN05_008390)1632054..1632341+288WP_000323025.1type II toxin-antitoxin system mRNA interferase RelEToxin
EKN05_RS08365 (EKN05_008395)1632413..1632568+156WP_000813254.1type I toxin-antitoxin system toxin HokD-
EKN05_RS08370 (EKN05_008400)1632786..1633037+252WP_000980987.1protein Rem-
EKN05_RS08375 (EKN05_008405)1633104..1633382+279WP_024258459.1hypothetical protein-
EKN05_RS08380 (EKN05_008410)1633384..1634434+1051Protein_1618DUF968 domain-containing protein-
EKN05_RS08385 (EKN05_008415)1634447..1634821+375WP_000904117.1RusA family crossover junction endodeoxyribonuclease-
EKN05_RS250851634818..1635639+822Protein_1620antitermination protein-
EKN05_RS08410 (EKN05_008440)1636222..1636500+279WP_001017801.1hypothetical protein-
EKN05_RS08415 (EKN05_008445)1636559..1636667+109Protein_1622DUF3927 family protein-
EKN05_RS08420 (EKN05_008450)1636948..1637283-336WP_000871291.1anti-adapter protein IraM-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--1629251..164327814027


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T120372 WP_000323025.1 NZ_CP037923:1632054-1632341 [Shigella flexneri 5a str. M90T]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T120372 NZ_CP037923:1632054-1632341 [Shigella flexneri 5a str. M90T]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT120372 WP_000534858.1 NZ_CP037923:1631815-1632054 [Shigella flexneri 5a str. M90T]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT120372 NZ_CP037923:1631815-1632054 [Shigella flexneri 5a str. M90T]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4V7K
PDB4V7J
PDB4FXI
PDB4FXE
PDB2KC8
PDB4FXH
PDB2KC9

Antitoxin

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Source
ID
Structure
PDB4FXE
PDB2KC8
PDB2K29
AlphaFold DBA0A4V1CTS8

References