95813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 742855..743381 Replicon chromosome
Accession NZ_CP026776
Organism Shigella flexneri strain 98-3193

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag C1P84_RS04060 Protein ID WP_000323025.1
Coordinates 742855..743142 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag C1P84_RS04065 Protein ID WP_000534858.1
Coordinates 743142..743381 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P84_RS04005 (737913) 737913..738248 + 336 WP_000871291.1 anti-adapter protein IraM -
C1P84_RS04010 (738529) 738529..738637 - 109 Protein_757 DUF3927 family protein -
C1P84_RS04030 (739558) 739558..740379 - 822 WP_000762884.1 antitermination protein -
C1P84_RS04035 (740394) 740394..740750 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
C1P84_RS04040 (740763) 740763..741812 - 1050 WP_001265249.1 DUF968 domain-containing protein -
C1P84_RS04045 (741814) 741814..742092 - 279 Protein_761 hypothetical protein -
C1P84_RS04050 (742195) 742195..742410 - 216 WP_000980986.1 hypothetical protein -
C1P84_RS04055 (742628) 742628..742783 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
C1P84_RS04060 (742855) 742855..743142 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
C1P84_RS04065 (743142) 743142..743381 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
C1P84_RS04070 (743406) 743406..743711 + 306 WP_071818640.1 hypothetical protein -
C1P84_RS04075 (743708) 743708..744586 - 879 Protein_767 IS3-like element IS600 family transposase -
C1P84_RS04085 (745358) 745358..745786 + 429 Protein_769 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 734716..753511 18795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T95813 WP_000323025.1 NZ_CP026776:c743142-742855 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T95813 NZ_CP026776:c743142-742855 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT95813 WP_000534858.1 NZ_CP026776:c743381-743142 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT95813 NZ_CP026776:c743381-743142 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References