95979

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4215728..4216254 Replicon chromosome
Accession NZ_CP026793
Organism Shigella flexneri strain 74-1170

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag C1P81_RS21465 Protein ID WP_000323025.1
Coordinates 4215728..4216015 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag C1P81_RS21470 Protein ID WP_000534858.1
Coordinates 4216015..4216254 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P81_RS21410 (4210786) 4210786..4211121 + 336 WP_000871291.1 anti-adapter protein IraM -
C1P81_RS21415 (4211402) 4211402..4211510 - 109 Protein_4112 DUF3927 family protein -
C1P81_RS21435 (4212431) 4212431..4213252 - 822 WP_000762882.1 antitermination protein -
C1P81_RS21440 (4213267) 4213267..4213623 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
C1P81_RS21445 (4213636) 4213636..4214685 - 1050 WP_001265249.1 DUF968 domain-containing protein -
C1P81_RS21450 (4214687) 4214687..4214965 - 279 Protein_4116 hypothetical protein -
C1P81_RS21455 (4215032) 4215032..4215283 - 252 WP_000980987.1 protein Rem -
C1P81_RS21460 (4215501) 4215501..4215656 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
C1P81_RS21465 (4215728) 4215728..4216015 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
C1P81_RS21470 (4216015) 4216015..4216254 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
C1P81_RS21475 (4216279) 4216279..4216584 + 306 WP_071818640.1 hypothetical protein -
C1P81_RS21485 (4217799) 4217799..4218818 + 1020 Protein_4123 MHS family MFS transporter YdfJ -
C1P81_RS21490 (4218907) 4218907..4220367 + 1461 WP_000527804.1 mannitol dehydrogenase family protein -
C1P81_RS21495 (4220403) 4220403..4220606 - 204 WP_000214712.1 putative selenium delivery protein YdfZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4202469..4218818 16349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T95979 WP_000323025.1 NZ_CP026793:c4216015-4215728 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T95979 NZ_CP026793:c4216015-4215728 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT95979 WP_000534858.1 NZ_CP026793:c4216254-4216015 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT95979 NZ_CP026793:c4216254-4216015 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References