115085

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2589415..2589941 Replicon chromosome
Accession NZ_CP034060
Organism Shigella flexneri strain FDAARGOS_535

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EGX88_RS14585 Protein ID WP_000323025.1
Coordinates 2589415..2589702 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EGX88_RS14590 Protein ID WP_000534858.1
Coordinates 2589702..2589941 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX88_RS14530 (2584473) 2584473..2584808 + 336 WP_000871291.1 anti-adapter protein IraM -
EGX88_RS14535 (2585089) 2585089..2585197 - 109 Protein_2491 DUF3927 family protein -
EGX88_RS14555 (2586118) 2586118..2586939 - 822 WP_000762884.1 antitermination protein -
EGX88_RS14560 (2586954) 2586954..2587310 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
EGX88_RS14565 (2587323) 2587323..2588372 - 1050 WP_001265249.1 DUF968 domain-containing protein -
EGX88_RS14570 (2588374) 2588374..2588652 - 279 Protein_2495 hypothetical protein -
EGX88_RS14575 (2588755) 2588755..2588970 - 216 WP_000980986.1 hypothetical protein -
EGX88_RS14580 (2589188) 2589188..2589343 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EGX88_RS14585 (2589415) 2589415..2589702 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EGX88_RS14590 (2589702) 2589702..2589941 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EGX88_RS14595 (2589966) 2589966..2590271 + 306 WP_071818640.1 hypothetical protein -
EGX88_RS14600 (2590268) 2590268..2591146 - 879 Protein_2501 IS3 family transposase -
EGX88_RS14610 (2591885) 2591885..2592346 + 462 Protein_2503 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2581276..2594959 13683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T115085 WP_000323025.1 NZ_CP034060:c2589702-2589415 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T115085 NZ_CP034060:c2589702-2589415 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT115085 WP_000534858.1 NZ_CP034060:c2589941-2589702 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT115085 NZ_CP034060:c2589941-2589702 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References