26537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1636971..1637497 Replicon chromosome
Accession NC_017328
Organism Shigella flexneri 2002017

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag SFXV_RS09115 Protein ID WP_000323025.1
Coordinates 1636971..1637258 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag SFXV_RS09120 Protein ID WP_000534858.1
Coordinates 1637258..1637497 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFXV_RS09060 (1632029) 1632029..1632364 + 336 WP_000871291.1 anti-adapter protein IraM -
SFXV_RS30560 (1632645) 1632645..1632753 - 109 Protein_1665 DUF3927 family protein -
SFXV_RS09085 (1633674) 1633674..1634495 - 822 WP_000762882.1 antitermination protein -
SFXV_RS09090 (1634510) 1634510..1634866 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
SFXV_RS09095 (1634879) 1634879..1635928 - 1050 WP_001265249.1 DUF968 domain-containing protein -
SFXV_RS09100 (1635930) 1635930..1636208 - 279 Protein_1669 hypothetical protein -
SFXV_RS09105 (1636275) 1636275..1636526 - 252 WP_000980987.1 protein Rem -
SFXV_RS09110 (1636744) 1636744..1636899 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
SFXV_RS09115 (1636971) 1636971..1637258 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
SFXV_RS09120 (1637258) 1637258..1637497 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
SFXV_RS27985 (1637522) 1637522..1637827 + 306 WP_071818640.1 hypothetical protein -
SFXV_RS09125 (1637824) 1637824..1638980 - 1157 Protein_1675 IS3-like element IS600 family transposase -
SFXV_RS09135 (1639042) 1639042..1640061 + 1020 Protein_1676 MHS family MFS transporter YdfJ -
SFXV_RS09140 (1640150) 1640150..1641610 + 1461 WP_000527804.1 mannitol dehydrogenase family protein -
SFXV_RS09145 (1641646) 1641646..1641849 - 204 WP_000214712.1 putative selenium delivery protein YdfZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1628645..1640061 11416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T26537 WP_000323025.1 NC_017328:c1637258-1636971 [Shigella flexneri 2002017]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T26537 NC_017328:c1637258-1636971 [Shigella flexneri 2002017]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT26537 WP_000534858.1 NC_017328:c1637497-1637258 [Shigella flexneri 2002017]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT26537 NC_017328:c1637497-1637258 [Shigella flexneri 2002017]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References