246324

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1169247..1169773 Replicon chromosome
Accession NZ_CP097834
Organism Shigella flexneri strain C

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag M9379_RS05955 Protein ID WP_000323025.1
Coordinates 1169247..1169534 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag M9379_RS05960 Protein ID WP_000534858.1
Coordinates 1169534..1169773 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9379_RS05905 (1164305) 1164305..1164640 + 336 WP_000871291.1 anti-adapter protein IraM -
M9379_RS05910 (1164921) 1164921..1165029 - 109 Protein_1151 DUF3927 family protein -
M9379_RS05925 (1165950) 1165950..1166771 - 822 WP_000762884.1 antitermination protein -
M9379_RS05930 (1166786) 1166786..1167142 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
M9379_RS05935 (1167155) 1167155..1168204 - 1050 WP_001265249.1 DUF968 domain-containing protein -
M9379_RS05940 (1168206) 1168206..1168484 - 279 Protein_1155 hypothetical protein -
M9379_RS05945 (1168587) 1168587..1168802 - 216 WP_000980986.1 hypothetical protein -
M9379_RS05950 (1169020) 1169020..1169175 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
M9379_RS05955 (1169247) 1169247..1169534 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
M9379_RS05960 (1169534) 1169534..1169773 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
M9379_RS05965 (1169798) 1169798..1170103 + 306 WP_071818640.1 hypothetical protein -
M9379_RS05970 (1170100) 1170100..1170978 - 879 Protein_1161 IS3-like element IS600 family transposase -
M9379_RS05980 (1171750) 1171750..1172178 + 429 Protein_1163 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1161108..1174791 13683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T246324 WP_000323025.1 NZ_CP097834:c1169534-1169247 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT246324 WP_000534858.1 NZ_CP097834:c1169773-1169534 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References