45975

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1559649..1560175 Replicon chromosome
Accession NZ_CP007037
Organism Shigella flexneri G1663

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag SF2A_RS08560 Protein ID WP_000323025.1
Coordinates 1559888..1560175 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag SF2A_RS08555 Protein ID WP_000534858.1
Coordinates 1559649..1559888 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SF2A_RS08535 (1556899) 1556899..1557648 - 750 Protein_1559 fimbrial protein -
SF2A_RS08545 (1557704) 1557704..1558401 + 698 WP_252739101.1 IS1 family transposase -
SF2A_RS08550 (1558417) 1558417..1559322 + 906 Protein_1561 IS3-like element IS600 family transposase -
SF2A_RS27245 (1559319) 1559319..1559624 - 306 WP_094108346.1 hypothetical protein -
SF2A_RS08555 (1559649) 1559649..1559888 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
SF2A_RS08560 (1559888) 1559888..1560175 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
SF2A_RS08565 (1560247) 1560247..1560402 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
SF2A_RS08570 (1560620) 1560620..1560871 + 252 WP_000980987.1 protein Rem -
SF2A_RS08575 (1560938) 1560938..1561216 + 279 Protein_1567 hypothetical protein -
SF2A_RS08580 (1561218) 1561218..1562267 + 1050 WP_001265249.1 DUF968 domain-containing protein -
SF2A_RS08585 (1562280) 1562280..1562636 + 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
SF2A_RS08590 (1562651) 1562651..1563472 + 822 WP_000762882.1 antitermination protein -
SF2A_RS29625 (1564382) 1564382..1564490 + 109 Protein_1571 DUF3927 family protein -
SF2A_RS08615 (1564771) 1564771..1565106 - 336 WP_000871291.1 anti-adapter protein IraM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1551940..1568303 16363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T45975 WP_000323025.1 NZ_CP007037:1559888-1560175 [Shigella flexneri G1663]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T45975 NZ_CP007037:1559888-1560175 [Shigella flexneri G1663]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT45975 WP_000534858.1 NZ_CP007037:1559649-1559888 [Shigella flexneri G1663]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT45975 NZ_CP007037:1559649-1559888 [Shigella flexneri G1663]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References