246308

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3213278..3213804 Replicon chromosome
Accession NZ_CP097831
Organism Shigella flexneri strain D

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag M9381_RS15900 Protein ID WP_000323025.1
Coordinates 3213278..3213565 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag M9381_RS15905 Protein ID WP_000534858.1
Coordinates 3213565..3213804 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9381_RS15850 (3208336) 3208336..3208671 + 336 WP_000871291.1 anti-adapter protein IraM -
M9381_RS15855 (3208952) 3208952..3209060 - 109 Protein_3082 DUF3927 family protein -
M9381_RS15870 (3209981) 3209981..3210802 - 822 WP_000762884.1 antitermination protein -
M9381_RS15875 (3210817) 3210817..3211173 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
M9381_RS15880 (3211186) 3211186..3212235 - 1050 WP_001265249.1 DUF968 domain-containing protein -
M9381_RS15885 (3212237) 3212237..3212515 - 279 Protein_3086 hypothetical protein -
M9381_RS15890 (3212618) 3212618..3212833 - 216 WP_000980986.1 hypothetical protein -
M9381_RS15895 (3213051) 3213051..3213206 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
M9381_RS15900 (3213278) 3213278..3213565 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
M9381_RS15905 (3213565) 3213565..3213804 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
M9381_RS15910 (3213829) 3213829..3214134 + 306 WP_071818640.1 hypothetical protein -
M9381_RS15915 (3214131) 3214131..3215009 - 879 Protein_3092 IS3-like element IS600 family transposase -
M9381_RS15925 (3215781) 3215781..3216209 + 429 Protein_3094 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3205139..3223934 18795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T246308 WP_000323025.1 NZ_CP097831:c3213565-3213278 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT246308 WP_000534858.1 NZ_CP097831:c3213804-3213565 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References