20387

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2010870..2011177 Replicon chromosome
Accession NC_002745
Organism Staphylococcus aureus subsp. aureus N315

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag SA_RS14820 Protein ID WP_011447039.1
Coordinates 2011001..2011177 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2010870..2011009 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA_RS10080 2006215..2006475 + 261 WP_001791826.1 hypothetical protein -
SA_RS10085 (SA1754) 2006528..2006878 - 351 WP_000702262.1 complement inhibitor SCIN-A -
SA_RS10090 (SA1755) 2007561..2008010 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
SA_RS10095 2008105..2008439 - 335 Protein_1877 SH3 domain-containing protein -
SA_RS10100 (SA1758) 2009086..2009577 - 492 WP_000920042.1 staphylokinase -
SA_RS10105 (SA1759) 2009768..2010523 - 756 WP_000861026.1 CHAP domain-containing protein -
SA_RS10110 (SA1760) 2010535..2010789 - 255 WP_000611512.1 phage holin -
- 2010870..2011009 + 140 - - Antitoxin
SA_RS14820 2011001..2011177 - 177 WP_011447039.1 putative holin-like toxin Toxin
SA_RS10125 (SA1761) 2011380..2012153 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
SA_RS10130 (SA1762) 2012574..2012948 - 375 WP_000340977.1 hypothetical protein -
SA_RS10135 (SA1763) 2013004..2013291 - 288 WP_001262621.1 hypothetical protein -
SA_RS10140 (SAS061) 2013337..2013489 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 2006528..2074317 67789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T20387 WP_011447039.1 NC_002745:c2011177-2011001 [Staphylococcus aureus subsp. aureus N315]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T20387 NC_002745:c2011177-2011001 [Staphylococcus aureus subsp. aureus N315]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT20387 NC_002745:2010870-2011009 [Staphylococcus aureus subsp. aureus N315]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References